Transcriptional elongation checkpoint control in development and disease

Transcriptional elongation control by RNA polymerase II and its associated factors has taken center stage as a process essential for the regulation of gene expression throughout development. In this review, we analyze recent findings on the identification of factors functioning in the regulation of...

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Bibliographic Details
Published in:Genes & development 2013-05, Vol.27 (10), p.1079-1088
Main Authors: Smith, Edwin, Shilatifard, Ali
Format: Article
Language:English
Subjects:
Animals
Chromatin - enzymology
Chromatin - genetics
Disease
Humans
Neoplasms - enzymology
Neoplasms - genetics
Phosphorylation
Review
RNA Polymerase II - metabolism
Stem Cells - enzymology
Stem Cells - metabolism
Transcription Elongation, Genetic
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Summary:Transcriptional elongation control by RNA polymerase II and its associated factors has taken center stage as a process essential for the regulation of gene expression throughout development. In this review, we analyze recent findings on the identification of factors functioning in the regulation of the transcriptional elongation checkpoint control (TECC) stage of gene expression and how the factors' misregulation is associated with disease pathogenesis, including cancer.
ISSN:0890-9369
1549-5477
DOI:10.1101/gad.215137.113