Development of Channeled Nanofibrous Scaffolds for Oriented Tissue Engineering

A tissue‐engineering scaffold resembling the structure of the natural extracellular matrix can often facilitate tissue regeneration. Nerve and tendon are oriented micro‐scale tissue bundles. In this study, a method combining injection molding and thermally induced phase separation techniques is deve...

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Bibliographic Details
Published in:Macromolecular bioscience 2012-06, Vol.12 (6), p.761-769
Main Authors: Sun, Chenghui, Jin, Xiaobing, Holzwarth, Jeremy M., Liu, Xiaohua, Hu, Jiang, Gupte, Melanie J., Zhao, Yaoming, Ma, Peter X.
Format: Article
Language:English
Subjects:
Animals
Applied sciences
Biological and medical sciences
Exact sciences and technology
fibers
Fibers and threads
Fibroblasts - cytology
Fibroblasts - metabolism
Forms of application and semi-finished materials
Lactic Acid - chemistry
Medical sciences
Nanofibers - chemistry
Nanofibers - ultrastructure
Nerve Regeneration
nerves
Neurons - cytology
Neurons - metabolism
PC12 Cells
Polyesters
Polymer industry, paints, wood
Polymers - chemistry
Porosity
Rabbits
Rats
scaffolds
Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases
Technology of polymers
Technology. Biomaterials. Equipments
tendons
Tendons - cytology
Tendons - metabolism
tissue engineering
Tissue Engineering - methods
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Summary:A tissue‐engineering scaffold resembling the structure of the natural extracellular matrix can often facilitate tissue regeneration. Nerve and tendon are oriented micro‐scale tissue bundles. In this study, a method combining injection molding and thermally induced phase separation techniques is developed to create single‐ and multiple‐channeled nanofibrous poly(L‐lactic acid) scaffolds. The overall shape, the number and spatial arrangement of channels, the channel wall matrix architecture, the porosity and mechanical properties of the scaffolds are all tunable. The porous NF channel wall matrix provides an excellent microenvironment for protein adsorption and the attachment of PC12 neuronal cells and tendon fibroblast cells, showing potential for neural and tendon tissue regeneration. A method combining injection molding and thermally induced phase separation is developed to create single‐ and multiple‐channeled nanofibrous polymer scaffolds. The porous nanofibrous channel wall provides an excellent microenvironment for protein adsorption and cell attachment, showing potential for nerve and tendon regeneration.
ISSN:1616-5187
1616-5195
DOI:10.1002/mabi.201200004