Genetic structure of Triatoma infestans populations in rural communities of Santiago del Estero, northern Argentina

To gain an understanding of the genetic structure and dispersal dynamics of Triatoma infestans populations, we analyzed the multilocus genotype of 10 microsatellite loci for 352 T. infestans collected in 21 houses of 11 rural communities in October 2002. Genetic structure was analyzed at the communi...

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Bibliographic Details
Published in:Infection, genetics and evolution genetics and evolution, 2008-12, Vol.8 (6), p.835-846
Main Authors: Marcet, P.L., Mora, M.S., Cutrera, A.P., Jones, L., Gürtler, R.E., Kitron, U., Dotson, E.M.
Format: Article
Language:English
Subjects:
Analysis of Variance
Animals
Argentina - epidemiology
Bayes Theorem
Chagas disease
Chagas Disease - epidemiology
Chagas Disease - genetics
Chagas Disease - transmission
Female
Genetic Variation
Humans
Insect Control
Insect Vectors - genetics
Insect Vectors - physiology
Insecticides
Linkage Disequilibrium
Male
Microsatellite loci
Microsatellite Repeats
Monte Carlo Method
Polymerase Chain Reaction
Population Dynamics
Population structure
Rural Population
Sex Distribution
Triatoma - genetics
Triatoma - physiology
Triatoma infestans
Vector control
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Summary:To gain an understanding of the genetic structure and dispersal dynamics of Triatoma infestans populations, we analyzed the multilocus genotype of 10 microsatellite loci for 352 T. infestans collected in 21 houses of 11 rural communities in October 2002. Genetic structure was analyzed at the community and house compound levels. Analysis revealed that vector control actions affected the genetic structure of T. infestans populations. Bug populations from communities under sustained vector control (core area) were highly structured and genetic differentiation between neighboring house compounds was significant. In contrast, bug populations from communities with sporadic vector control actions were more homogeneous and lacked defined genetic clusters. Genetic differentiation between population pairs did not fit a model of isolation by distance at the microgeographical level. Evidence consistent with flight or walking bug dispersal was detected within and among communities, dispersal was more female-biased in the core area and results suggested that houses received immigrants from more than one source. Putative sources and mechanisms of re-infestation are described. These data may be use to design improved vector control strategies.
ISSN:1567-1348
1567-7257
DOI:10.1016/j.meegid.2008.08.002