Relationship Between Clinical Outcome Measures and Parent Proxy Reports of Health-Related Quality of Life in Ambulatory Children With Duchenne Muscular Dystrophy

• Published in: Journal of child neurology 2010-09, Vol.25 (9), p.1130-1144
• Main Authors: McDonald, Craig M., McDonald, Dawn A., Bagley, Anita, Sienko Thomas, Susan, Buckon, Cathleen E., Henricson, Eric, Nicorici, Alina, Sussman, Michael D.
• Format: Article
• Language: English
• Subjects: Adolescent; Child; Child, Preschool; Clinical Trials as Topic - psychology; Health Surveys - methods; Humans; Male; Muscular Dystrophy, Duchenne - physiopathology; Muscular Dystrophy, Duchenne - psychology; Muscular Dystrophy, Duchenne - therapy; Office Visits - statistics & numerical data; Outcome Assessment, Health Care - methods; Outpatients - psychology; Parents - psychology; Quality of Life - psychology; Surveys and Questionnaires - standards
• ISSN: 0883-0738; 1708-8283
• DOI: 10.1177/0883073810371509

In Duchenne muscular dystrophy, data directly linking changes in clinical outcome measures to patient-perceived well-being are lacking. This study evaluated the relationship between clinical outcome measures used in clinical trials of ambulatory Duchenne muscular dystrophy (Vignos functional grade, quantitative knee extension strength, timed functional performance measures, and gait velocity) and 2 health-related quality of life measures—the Pediatric Outcomes Data Collection Instrument and Pediatric Quality of Life Inventory—in 52 ambulatory Duchenne muscular dystrophy subjects and 36 controls. Those with the disease showed significant decrements in parent proxy-reported health-related quality of life measures versus controls across all domains. The Pediatric Outcomes Data Collection Instrument transfers/basic mobility and sports/ physical function and the Pediatric Quality of Life Inventory physical functioning domains had significant associations with age (and hence disease progression) and traditional clinical outcome measures employed in clinical trials of ambulatory boys with Duchenne muscular dystrophy. Selected domains of the Pediatric Outcomes Data Collection Instrument and generic Pediatric Quality of Life Inventory are potential patient-reported outcome measures for clinical trials in ambulatory individuals with the disease.