The ultra-early protective effect of ulinastatin on rabbit acute lung injury induced by paraquat

To study ultra-early pathophysiological changes of rabbit acute lung injury (ALI) caused by paraquat (PQ) and discuss the ultra-early protective effect of ulinastatin on rabbit ALI due to PQ. 30 New Zealand white rabbits were randomly divided into a control group, a paraquat group and an ulinastatin...

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Published in:BMC emergency medicine 2013-07, Vol.13 Suppl 1 (S1), p.S7-S7, Article S7
Main Authors: Song, Zujun, Chen, Gaofei, Lin, Gang, Jia, Chiyu, Cao, Jianxia, Ao, Guokun
Format: Article
Language:English
Subjects:
Acute Lung Injury - chemically induced
Acute Lung Injury - drug therapy
Acute Lung Injury - pathology
Acute Lung Injury - physiopathology
Analysis of Variance
Animals
Capillaries - pathology
Female
Glycoproteins - therapeutic use
Lung - blood supply
Lung - pathology
Lung - ultrastructure
Male
Multidetector Computed Tomography
Paraquat
Proceedings
Rabbits
Regional Blood Flow
Time Factors
Trypsin Inhibitors - therapeutic use
Vascular Endothelial Growth Factor A - blood
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creator Song, Zujun
Chen, Gaofei
Lin, Gang
Jia, Chiyu
Cao, Jianxia
Ao, Guokun
description To study ultra-early pathophysiological changes of rabbit acute lung injury (ALI) caused by paraquat (PQ) and discuss the ultra-early protective effect of ulinastatin on rabbit ALI due to PQ. 30 New Zealand white rabbits were randomly divided into a control group, a paraquat group and an ulinastatin intervention group with 10 rabbits in each group. For paraquat group and intervention group a single dose of paraquat (35 mg/kg) was injected intraperitoneally to establish rabbit models of ALI. The control group was injected an equal volume of saline. The intervention group was treated with 100 Ku/kg ulinastatin immediately after the establishment of the ALI model. The respective experimental groups underwent 320-slice CT perfusion scan of pleural at 2h, 4h and 6h time point after modeling to get CTP (CT Perfusion) images and related parameters. 2 mL blood was collected in the marginal ear vein to determine the mass concentration of the vascular endothelial growth factor (VEGF). The animals were killed by air embolism after 6h and lung tissue was taken for pathology observation. The reginal blood flow (rBF) and reginal blood volume (rBV) of paraquat group at 2,4,6 h time point were significantly (P
doi_str_mv 10.1186/1471-227X-13-S1-S7
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For paraquat group and intervention group a single dose of paraquat (35 mg/kg) was injected intraperitoneally to establish rabbit models of ALI. The control group was injected an equal volume of saline. The intervention group was treated with 100 Ku/kg ulinastatin immediately after the establishment of the ALI model. The respective experimental groups underwent 320-slice CT perfusion scan of pleural at 2h, 4h and 6h time point after modeling to get CTP (CT Perfusion) images and related parameters. 2 mL blood was collected in the marginal ear vein to determine the mass concentration of the vascular endothelial growth factor (VEGF). The animals were killed by air embolism after 6h and lung tissue was taken for pathology observation. The reginal blood flow (rBF) and reginal blood volume (rBV) of paraquat group at 2,4,6 h time point were significantly (P <0.05) lower than those of control group. The intervention group rBF and rBV at 2, 4 and 6 h time points were significantly higher (P <0.05) compared to paraquat group. The permeability surface (rPS) and VEGF mass concentration of paraquat group at 2,4,6 h time point were significantly higher than the control group (P <0.05), and the intervention group rPS and VEGF mass concentrations at 2,4,6h time point were significantly lower (P <0.05) than those of paraquat group. Pathological detection indicators of paraquat group (congestive capillary percentage, the number of red blood cells outside of capillaries, percentage of capillaries with basement membrane damage) were significantly higher (P <0.05) at 6h time point compared with the control group, while significantly lower (P <0.05) in intervention group than in paraquat groups. Pathological observation under light microscope showed in paraquat group obvious inflammatory cell infiltration, alveolar epithelial cell hyperplasia, widened alveolar septum, visible focal hemorrhage, visible acute and chronic inflammatory cell infiltration in bronchioles cavity; under electron microscopy alveolar epithelial cell degeneration and necrosis, vascular welling of the endothelial cells, basement membrane rupture, a lot of exudates in alveolar space. In the intervention group, the above the symptoms were mitigated. In the ultra-early stage of rabbit ALI induced by PQ, pulmonary vascular endothelial cell is damaged and serum VEGF mass concentration and pulmonary vascular permeability increase. Early ulinastatin intervention can reduce serum VEGF level and PQ-induced vascular permeability amplitude, indicating that ulinastatin has a protective effect on pulmonary vascular endothelial cells.]]></description><identifier>ISSN: 1471-227X</identifier><identifier>EISSN: 1471-227X</identifier><identifier>DOI: 10.1186/1471-227X-13-S1-S7</identifier><identifier>PMID: 23902632</identifier><language>eng</language><publisher>England: BioMed Central</publisher><subject>Acute Lung Injury - chemically induced ; Acute Lung Injury - drug therapy ; Acute Lung Injury - pathology ; Acute Lung Injury - physiopathology ; Analysis of Variance ; Animals ; Capillaries - pathology ; Female ; Glycoproteins - therapeutic use ; Lung - blood supply ; Lung - pathology ; Lung - ultrastructure ; Male ; Multidetector Computed Tomography ; Paraquat ; Proceedings ; Rabbits ; Regional Blood Flow ; Time Factors ; Trypsin Inhibitors - therapeutic use ; Vascular Endothelial Growth Factor A - blood</subject><ispartof>BMC emergency medicine, 2013-07, Vol.13 Suppl 1 (S1), p.S7-S7, Article S7</ispartof><rights>2013 Song et al; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.</rights><rights>Copyright © 2013 Song et al; licensee BioMed Central Ltd. 2013 Song et al; licensee BioMed Central Ltd.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-b541t-d856d718f6d4d33771c84adeafb67db2bb3a10aa86a3e2fe62d213ccca0d724c3</citedby><cites>FETCH-LOGICAL-b541t-d856d718f6d4d33771c84adeafb67db2bb3a10aa86a3e2fe62d213ccca0d724c3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3701465/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.proquest.com/docview/1399100202?pq-origsite=primo$$EHTML$$P50$$Gproquest$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,885,25751,27922,27923,37010,44588,53789,53791</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/23902632$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Song, Zujun</creatorcontrib><creatorcontrib>Chen, Gaofei</creatorcontrib><creatorcontrib>Lin, Gang</creatorcontrib><creatorcontrib>Jia, Chiyu</creatorcontrib><creatorcontrib>Cao, Jianxia</creatorcontrib><creatorcontrib>Ao, Guokun</creatorcontrib><title>The ultra-early protective effect of ulinastatin on rabbit acute lung injury induced by paraquat</title><title>BMC emergency medicine</title><addtitle>BMC Emerg Med</addtitle><description><![CDATA[To study ultra-early pathophysiological changes of rabbit acute lung injury (ALI) caused by paraquat (PQ) and discuss the ultra-early protective effect of ulinastatin on rabbit ALI due to PQ. 30 New Zealand white rabbits were randomly divided into a control group, a paraquat group and an ulinastatin intervention group with 10 rabbits in each group. For paraquat group and intervention group a single dose of paraquat (35 mg/kg) was injected intraperitoneally to establish rabbit models of ALI. The control group was injected an equal volume of saline. The intervention group was treated with 100 Ku/kg ulinastatin immediately after the establishment of the ALI model. The respective experimental groups underwent 320-slice CT perfusion scan of pleural at 2h, 4h and 6h time point after modeling to get CTP (CT Perfusion) images and related parameters. 2 mL blood was collected in the marginal ear vein to determine the mass concentration of the vascular endothelial growth factor (VEGF). The animals were killed by air embolism after 6h and lung tissue was taken for pathology observation. The reginal blood flow (rBF) and reginal blood volume (rBV) of paraquat group at 2,4,6 h time point were significantly (P <0.05) lower than those of control group. 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Early ulinastatin intervention can reduce serum VEGF level and PQ-induced vascular permeability amplitude, indicating that ulinastatin has a protective effect on pulmonary vascular endothelial cells.]]></description><subject>Acute Lung Injury - chemically induced</subject><subject>Acute Lung Injury - drug therapy</subject><subject>Acute Lung Injury - pathology</subject><subject>Acute Lung Injury - physiopathology</subject><subject>Analysis of Variance</subject><subject>Animals</subject><subject>Capillaries - pathology</subject><subject>Female</subject><subject>Glycoproteins - therapeutic use</subject><subject>Lung - blood supply</subject><subject>Lung - pathology</subject><subject>Lung - ultrastructure</subject><subject>Male</subject><subject>Multidetector Computed Tomography</subject><subject>Paraquat</subject><subject>Proceedings</subject><subject>Rabbits</subject><subject>Regional Blood Flow</subject><subject>Time Factors</subject><subject>Trypsin Inhibitors - therapeutic use</subject><subject>Vascular Endothelial Growth Factor A - blood</subject><issn>1471-227X</issn><issn>1471-227X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2013</creationdate><recordtype>article</recordtype><sourceid>PIMPY</sourceid><recordid>eNp1kU1rGzEQhkVpaBw3f6CHIuh5U420Xq0vhRLSpBDIwQnkpow-1pFZr2ytFPC_r4xTk0B7mmHmnUd6Zwj5AuwCoG2-Qy2h4lw-ViCqBVQL-YFMjsWPb_JTcjaOK8ZAtjD_RE65mDPeCD4hT_fPjuY-Rawcxn5HNzEkZ5J_cdR1Xclo6IrADzgmTH6gYaARtfaJosnJ0T4PS-qHVY67Emw2zlJdOBhxmzF9Jicd9qM7f41T8vDr6v7yprq9u_59-fO20rMaUmXbWWMltF1jayuElGDaGq3DTjfSaq61QGCIbYPC8c413HIQxhhkVvLaiCn5ceBusl47a9xQPPVqE_0a404F9Op9Z_DPahlelJAM6mZWAFcHgPbhP4D3HRPWar9htd-wAqEWoBaycL69fiSGbXZjUquQ41C8F818DoxxxouKH1QmhnGMrjs-BEztr_tv9Ne3Ho8jf88p_gBAnqSk</recordid><startdate>20130704</startdate><enddate>20130704</enddate><creator>Song, Zujun</creator><creator>Chen, Gaofei</creator><creator>Lin, Gang</creator><creator>Jia, Chiyu</creator><creator>Cao, Jianxia</creator><creator>Ao, Guokun</creator><general>BioMed Central</general><general>BioMed Central Ltd</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>M7N</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>5PM</scope></search><sort><creationdate>20130704</creationdate><title>The ultra-early protective effect of ulinastatin on rabbit acute lung injury induced by paraquat</title><author>Song, Zujun ; Chen, Gaofei ; Lin, Gang ; Jia, Chiyu ; Cao, Jianxia ; Ao, Guokun</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-b541t-d856d718f6d4d33771c84adeafb67db2bb3a10aa86a3e2fe62d213ccca0d724c3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2013</creationdate><topic>Acute Lung Injury - chemically induced</topic><topic>Acute Lung Injury - drug therapy</topic><topic>Acute Lung Injury - pathology</topic><topic>Acute Lung Injury - physiopathology</topic><topic>Analysis of Variance</topic><topic>Animals</topic><topic>Capillaries - pathology</topic><topic>Female</topic><topic>Glycoproteins - therapeutic use</topic><topic>Lung - blood supply</topic><topic>Lung - pathology</topic><topic>Lung - ultrastructure</topic><topic>Male</topic><topic>Multidetector Computed Tomography</topic><topic>Paraquat</topic><topic>Proceedings</topic><topic>Rabbits</topic><topic>Regional Blood Flow</topic><topic>Time Factors</topic><topic>Trypsin Inhibitors - therapeutic use</topic><topic>Vascular Endothelial Growth Factor A - blood</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Song, Zujun</creatorcontrib><creatorcontrib>Chen, Gaofei</creatorcontrib><creatorcontrib>Lin, Gang</creatorcontrib><creatorcontrib>Jia, Chiyu</creatorcontrib><creatorcontrib>Cao, Jianxia</creatorcontrib><creatorcontrib>Ao, Guokun</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>ProQuest Health &amp; 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For paraquat group and intervention group a single dose of paraquat (35 mg/kg) was injected intraperitoneally to establish rabbit models of ALI. The control group was injected an equal volume of saline. The intervention group was treated with 100 Ku/kg ulinastatin immediately after the establishment of the ALI model. The respective experimental groups underwent 320-slice CT perfusion scan of pleural at 2h, 4h and 6h time point after modeling to get CTP (CT Perfusion) images and related parameters. 2 mL blood was collected in the marginal ear vein to determine the mass concentration of the vascular endothelial growth factor (VEGF). The animals were killed by air embolism after 6h and lung tissue was taken for pathology observation. The reginal blood flow (rBF) and reginal blood volume (rBV) of paraquat group at 2,4,6 h time point were significantly (P <0.05) lower than those of control group. The intervention group rBF and rBV at 2, 4 and 6 h time points were significantly higher (P <0.05) compared to paraquat group. The permeability surface (rPS) and VEGF mass concentration of paraquat group at 2,4,6 h time point were significantly higher than the control group (P <0.05), and the intervention group rPS and VEGF mass concentrations at 2,4,6h time point were significantly lower (P <0.05) than those of paraquat group. Pathological detection indicators of paraquat group (congestive capillary percentage, the number of red blood cells outside of capillaries, percentage of capillaries with basement membrane damage) were significantly higher (P <0.05) at 6h time point compared with the control group, while significantly lower (P <0.05) in intervention group than in paraquat groups. Pathological observation under light microscope showed in paraquat group obvious inflammatory cell infiltration, alveolar epithelial cell hyperplasia, widened alveolar septum, visible focal hemorrhage, visible acute and chronic inflammatory cell infiltration in bronchioles cavity; under electron microscopy alveolar epithelial cell degeneration and necrosis, vascular welling of the endothelial cells, basement membrane rupture, a lot of exudates in alveolar space. In the intervention group, the above the symptoms were mitigated. In the ultra-early stage of rabbit ALI induced by PQ, pulmonary vascular endothelial cell is damaged and serum VEGF mass concentration and pulmonary vascular permeability increase. Early ulinastatin intervention can reduce serum VEGF level and PQ-induced vascular permeability amplitude, indicating that ulinastatin has a protective effect on pulmonary vascular endothelial cells.]]></abstract><cop>England</cop><pub>BioMed Central</pub><pmid>23902632</pmid><doi>10.1186/1471-227X-13-S1-S7</doi><oa>free_for_read</oa></addata></record>
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subjects Acute Lung Injury - chemically induced
Acute Lung Injury - drug therapy
Acute Lung Injury - pathology
Acute Lung Injury - physiopathology
Analysis of Variance
Animals
Capillaries - pathology
Female
Glycoproteins - therapeutic use
Lung - blood supply
Lung - pathology
Lung - ultrastructure
Male
Multidetector Computed Tomography
Paraquat
Proceedings
Rabbits
Regional Blood Flow
Time Factors
Trypsin Inhibitors - therapeutic use
Vascular Endothelial Growth Factor A - blood
title The ultra-early protective effect of ulinastatin on rabbit acute lung injury induced by paraquat
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