Neurogenesis continues in the third trimester of pregnancy and is suppressed by premature birth

Premature infants exhibit neurodevelopmental delay and reduced growth of the cerebral cortex. However, the underlying mechanisms have remained elusive. Therefore, we hypothesized that neurogenesis in the ventricular and subventricular zones of the cerebral cortex would continue in the third trimeste...

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Bibliographic Details
Published in:The Journal of neuroscience 2013-01, Vol.33 (2), p.411-423
Main Authors: Malik, Sabrina, Vinukonda, Govindaiah, Vose, Linnea R, Diamond, Daniel, Bhimavarapu, Bala B R, Hu, Furong, Zia, Muhammad T, Hevner, Robert, Zecevic, Nada, Ballabh, Praveen
Format: Article
Language:English
Subjects:
Adult
Animals
beta Catenin - physiology
Cell Count
Cerebral Ventricles - growth & development
Erythropoietin - physiology
Female
Gestational Age
Glycine - pharmacology
Humans
Hypoxia - physiopathology
Hypoxia-Inducible Factor 1 - biosynthesis
Hypoxia-Inducible Factor 1 - physiology
Immunohistochemistry
Infant, Newborn
Infant, Premature
Male
Nerve Tissue Proteins - biosynthesis
Neural Stem Cells - physiology
Neurogenesis - physiology
Pregnancy
Pregnancy Trimester, Third - physiology
Premature Birth - physiopathology
Rabbits
Signal Transduction - physiology
Telencephalon - growth & development
Vascular Endothelial Growth Factor A - physiology
Wnt Proteins - physiology
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Summary:Premature infants exhibit neurodevelopmental delay and reduced growth of the cerebral cortex. However, the underlying mechanisms have remained elusive. Therefore, we hypothesized that neurogenesis in the ventricular and subventricular zones of the cerebral cortex would continue in the third trimester of pregnancy and that preterm birth would suppress neurogenesis. To test our hypotheses, we evaluated autopsy materials from human fetuses and preterm infants of 16-35 gestational weeks (gw). We noted that both cycling and noncycling Sox2(+) radial glial cells and Tbr2(+) intermediate progenitors were abundant in human preterm infants until 28 gw. However, their densities consistently decreased from 16 through 28 gw. To determine the effect of premature birth on neurogenesis, we used a rabbit model and compared preterm [embryonic day 29 (E29), 3 d old] and term (E32,
ISSN:0270-6474
1529-2401
1529-2401
DOI:10.1523/jneurosci.4445-12.2013