Polypyrrole Hollow Microspheres as Echogenic Photothermal Agent for Ultrasound Imaging Guided Tumor Ablation

Ultrasound (US) imaging provides a valuable opportunity to administer photothermal therapy (PTT) of cancer with real-time guidance to ensure proper targeting, but only a few theranostic agents were developed by physically grafting near infrared (NIR)-absorbing inorganic nanomaterials to ready-made u...

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Bibliographic Details
Published in:Scientific reports 2013-08, Vol.3 (1), p.2360-2360, Article 2360
Main Authors: Zha, Zhengbao, Wang, Jinrui, Qu, Enze, Zhang, Shuhai, Jin, Yushen, Wang, Shumin, Dai, Zhifei
Format: Article
Language:English
Subjects:
639/301/54
639/301/54/990
639/301/923
639/925/352
Ablation
Animals
Cancer
Cell Line, Tumor
Contrast Media
Humanities and Social Sciences
Humans
Microspheres
multidisciplinary
Nanotechnology
Neoplasms, Experimental - diagnostic imaging
Neoplasms, Experimental - pathology
Neoplasms, Experimental - therapy
Photosensitizing Agents - therapeutic use
Phototherapy - methods
Polymers - therapeutic use
Pyrroles - therapeutic use
Rabbits
Science
Treatment Outcome
Ultrasonic imaging
Ultrasonography, Interventional - methods
Ultrasound
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Summary:Ultrasound (US) imaging provides a valuable opportunity to administer photothermal therapy (PTT) of cancer with real-time guidance to ensure proper targeting, but only a few theranostic agents were developed by physically grafting near infrared (NIR)-absorbing inorganic nanomaterials to ready-made ultrasound contrast agents (UCAs) for US imaging guided PTT. In this paper, NIR absorbing hollow microspheres were generated from polypyrrole merely using a facile one-step microemulsion method. It was found that the obtained polypyrrole hollow microspheres (PPyHMs) can act as an efficient theranostic agent not only to enhance US imaging greatly, but also exhibit excellent photohyperthermic effects. The contrast consistently sustained the echo signals for no less than 5 min and the NIR laser light ablated the tumor completely within two weeks in the presence of PPyHMs. More importantly, no use of additional NIR absorber substantially minimizes an onetime dose of the theranostic agent.
ISSN:2045-2322
2045-2322
DOI:10.1038/srep02360