The effect of vitamin A supplementation on biochemical parameters in multiple sclerosis patients

• Published in: Iranian red crescent medical journal 2013-03, Vol.15 (3), p.194-198
• Main Authors: Jafarirad, Samyah, Siassi, Firiydun, Harirchian, Muhammad Husayn, Amani, Rida, Yaraghi, Ali Akbar Sabur, Bitarafan, Sama
• Format: Article
• Language: English
• Subjects: Biochemical markers; Diagnosis; Multiple sclerosis; Physiological effect; Vitamin A; التشخيص; الكيمياء الحيوية
• ISSN: 2074-1804; 2074-1812
• DOI: 10.5812/ircmj.3480

Background : Vitamin A has different functions in the body and after being converted to acid form ; it can play many roles in immune system regulation. Therefore, this vitamin can be used as a supplement in the treatment of diseases, such as cancer and autoimmune diseases. Vitamin A is a fat-soluble compound and its long-term consumption in high doses can have some adverse effects. Objective : The current study aimed to investigate the possible complications and find solutions to minimize the adverse effects. Patients and Methods : This study was a double blind randomized clinical trial. In the main study, vitamin A (as retinyl palmitate) was given to 35 multiple sclerosis (MS) patients in order to regulate their immune system with a dose of 25000 IU / day for a period of six months. To investigate the possible biochemical complications, lipid profiles, fasting blood sugar (FBS), liver enzymes, and C-reactive protein (CRP) were tested. Results : Vitamin A did not have a significant difference in lipid profiles, FBS and liver enzymes between the two groups receiving vitamin A and the placebo, but CRP increased in patients who were taking vitamin A, 1.65 ± 0.43 (mg / L) and 2.88 ± 0.67, (Mean ± SEM), before and after the intervention respectively (P = 0.029), and statistical analysis showed significant differences with the group receiving placebo (P = 0.011) and CRP level in vitamin A group was 1.3 mg / L more than those of the placebo group after intervention (P = 0.011). Conclusions : Considering that no significant difference was found in the proven vitamin A side effects, due to the increase in CRP, frequent clinical and biochemical controls are required along with vitamin A supplementation.