Mechanisms of microbubble-vessel interactions and induced stresses: a numerical study

Oscillating microbubbles within microvessels could induce stresses that lead to bioeffects or vascular damage. Previous work has attributed vascular damage to the vessel expansion or bubble jet. However, ultra-high speed images of recent studies suggest that it could happen due to the vascular invag...

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Bibliographic Details
Published in:The Journal of the Acoustical Society of America 2013-09, Vol.134 (3), p.1875-1885
Main Authors: Hosseinkhah, N, Chen, H, Matula, T J, Burns, P N, Hynynen, K
Format: Article
Language:English
Subjects:
Animals
Computer Simulation
Contrast Media - adverse effects
Elasticity
Finite Element Analysis
Mesentery - blood supply
Microbubbles
Microvessels - diagnostic imaging
Microvessels - injuries
Models, Cardiovascular
Numerical Analysis, Computer-Assisted
Oscillometry
Pressure
Rats
Reproducibility of Results
Stress, Mechanical
Time Factors
Ultrasonics, Quantum Acoustics, and Physical Effects of Sound
Ultrasonography
Viscosity
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Summary:Oscillating microbubbles within microvessels could induce stresses that lead to bioeffects or vascular damage. Previous work has attributed vascular damage to the vessel expansion or bubble jet. However, ultra-high speed images of recent studies suggest that it could happen due to the vascular invagination. Numerical simulations of confined bubbles could provide insight into understanding the mechanism behind bubble-vessel interactions. In this study, a finite element model of a coupled bubble/fluid/vessel system was developed and validated with experimental data. Also, for a more realistic study viscoelastic properties of microvessels were assessed and incorporated into this comprehensive numerical model. The wall shear stress (WSS) and circumferential stress (CS), metrics of vascular damage, were calculated from these simulations. Resultant amplitudes of oscillation were within 15% of those measured in experiments (four cases). Among the experimental cases, it was numerically found that maximum WSS values were between 1.1-18.3 kPa during bubble expansion and 1.5-74 kPa during bubble collapse. CS was between 0.43-2.2 MPa during expansion and 0.44-6 MPa while invaginated. This finding confirmed that vascular damage could occur during vascular invaginations. Predicted thresholds in which these stresses are higher during vessel invagination were calculated from simulations.
ISSN:0001-4966
1520-8524
DOI:10.1121/1.4817843