Nonisothermal kinetics analysis of the dehydration of ziprasidone hydrochloride monohydrate by thermogravimetry

In the current work the kinetics of dehydration of ziprasidone hydrochloride monohydrate was studied by nonisothermal thermogravimetry. Ziprasidone hydrochloride monohydrate was heated from 30 to 150° with a heating rate of 5° per min under nitrogen gas atmosphere and weight loss data were collected...

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Bibliographic Details
Published in:Indian journal of pharmaceutical sciences 2013-05, Vol.75 (3), p.361-364
Main Authors: Ravikiran, A, Arthanareeswari, M, Kamaraj, P, Praveen, C
Format: Article
Language:English
Subjects:
Analysis
Chemical reaction, Rate of
Kinetics
Properties
Short Communications
Testing
Ziprasidone
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Summary:In the current work the kinetics of dehydration of ziprasidone hydrochloride monohydrate was studied by nonisothermal thermogravimetry. Ziprasidone hydrochloride monohydrate was heated from 30 to 150° with a heating rate of 5° per min under nitrogen gas atmosphere and weight loss data were collected. Powder X-ray difraction was used to characterize the solid before and after dehydration. The well accepted Coats-Redfern model fitting approach was applied to the thermogravimetry data for the kinetic analysis. Thirteen solid state reaction models were studied; among them one-dimensional diffusion model was found to be the best fit model for this reaction with an excellent correlation 0.9994. The Arrhenius parameters, activation energy, and pre-exponential factor were determined, the values were found to be 28 k.cal/mol and 9.53×10 13 sec−1 , respectively.
ISSN:0250-474X
1998-3743
DOI:10.4103/0250-474X.117416