Different indices of fetal growth predict bone size and volumetric density at 4 years of age

We have demonstrated previously that higher birth weight is associated with greater peak and later‐life bone mineral content and that maternal body build, diet, and lifestyle influence prenatal bone mineral accrual. To examine prenatal influences on bone health further, we related ultrasound measure...

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Bibliographic Details
Published in:Journal of bone and mineral research 2010-04, Vol.25 (4), p.920-927
Main Authors: Harvey, Nicholas C, Mahon, Pamela A, Robinson, Sian M, Nisbet, Corrine E, Javaid, M Kassim, Crozier, Sarah R, Inskip, Hazel M, Godfrey, Keith M, Arden, Nigel K, Dennison, Elaine M, Cooper, Cyrus
Format: Article
Language:English
Subjects:
Adult
Biological and medical sciences
Body Composition
Bone Density
Child, Preschool
developmental origins
epidemiology
Female
Femur - diagnostic imaging
Femur - growth & development
Fetal Development
Fundamental and applied biological sciences. Psychology
Humans
Liver - growth & development
Male
Organ Size
osteoporosis
Pregnancy
programming
Skeleton and joints
Ultrasonography, Prenatal
Vertebrates: osteoarticular system, musculoskeletal system
Waist Circumference
Young Adult
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Summary:We have demonstrated previously that higher birth weight is associated with greater peak and later‐life bone mineral content and that maternal body build, diet, and lifestyle influence prenatal bone mineral accrual. To examine prenatal influences on bone health further, we related ultrasound measures of fetal growth to childhood bone size and density. We derived Z‐scores for fetal femur length and abdominal circumference and conditional growth velocity from 19 to 34 weeks' gestation from ultrasound measurements in participants in the Southampton Women's Survey. A total of 380 of the offspring underwent dual‐energy X‐ray absorptiometry (DXA) at age 4 years [whole body minus head bone area (BA), bone mineral content (BMC), areal bone mineral density (aBMD), and estimated volumetric BMD (vBMD)]. Volumetric bone mineral density was estimated using BMC adjusted for BA, height, and weight. A higher velocity of 19‐ to 34‐week fetal femur growth was strongly associated with greater childhood skeletal size (BA: r = 0.30, p 
ISSN:0884-0431
1523-4681
DOI:10.1359/jbmr.091022