Role of the Carotid Body in the Pathophysiology of Heart Failure

Important recent advances implicate a role of the carotid body (CB) chemoreflex in sympathetic and breathing dysregulation in several cardio-respiratory diseases, drawing renewed interest in its potential implications for clinical treatment. Evidence from both chronic heart failure (CHF) patients an...

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Bibliographic Details
Published in:Current hypertension reports 2013-08, Vol.15 (4), p.356-362
Main Authors: Schultz, Harold D., Marcus, Noah J., Del Rio, Rodrigo
Format: Article
Language:English
Subjects:
Animals
Cardiology
Carotid Body - physiopathology
Disease Models, Animal
Family Medicine
General Practice
Heart Failure - etiology
Heart Failure - physiopathology
Humans
Hypertension
Hypertension - complications
Hypertension - physiopathology
Internal Medicine
Medicine
Medicine & Public Health
Metabolic Diseases
Nephrology
Primary Care Medicine
Reflex - physiology
Secondary Hypertension: Adrenal and Nervous System Mechanisms (S Oparil
Section Editor
Sympathetic Nervous System - physiopathology
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Summary:Important recent advances implicate a role of the carotid body (CB) chemoreflex in sympathetic and breathing dysregulation in several cardio-respiratory diseases, drawing renewed interest in its potential implications for clinical treatment. Evidence from both chronic heart failure (CHF) patients and animal models indicates that the CB chemoreflex is enhanced in CHF, and contributes to the tonic elevation in sympathetic nerve activity (SNA) and periodic breathing associated with the disease. Although this maladaptive change likely derives from altered function at all levels of the reflex arc, a change in afferent function of the CB is likely to be a main driving force. This review will focus on recent advances in our understanding of the pathophysiological mechanisms that alter CB function in CHF and their potential translational impact on treatment of chronic heart failure (CHF).
ISSN:1522-6417
1534-3111
DOI:10.1007/s11906-013-0368-x