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Glycopolymer probes of signal transduction

Glycans are key participants in biological processes ranging from reproduction to cellular communication to infection. Revealing glycan roles and the underlying molecular mechanisms by which glycans manifest their function requires access to glycan derivatives that vary systematically. To this end,...

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Published in:	Chemical Society reviews 2013-05, Vol.42 (10), p.4476-4491
Main Authors:	Kiessling, Laura L, Grim, Joseph C
Format:	Article
Language:	English
Subjects:	Bearing Biomimetic Materials - chemistry Biomimetic Materials - metabolism Carbohydrates Cellular communication Derivatives Glycan Glycopolymers Humans Molecular Probes - chemistry Molecular Probes - metabolism Mucins - chemistry Mucins - metabolism Polymers Polymers - chemistry polysaccharides Polysaccharides - chemistry Polysaccharides - metabolism Receptors, Cell Surface - chemistry Receptors, Cell Surface - metabolism Reproduction Signal Transduction
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description	Glycans are key participants in biological processes ranging from reproduction to cellular communication to infection. Revealing glycan roles and the underlying molecular mechanisms by which glycans manifest their function requires access to glycan derivatives that vary systematically. To this end, glycopolymers (polymers bearing pendant carbohydrates) have emerged as valuable glycan analogs. Because glycopolymers can readily be synthesized, their overall shape can be varied, and they can be altered systematically to dissect the structural features that underpin their activities. This review provides examples in which glycopolymers have been used to effect carbohydrate-mediated signal transduction. Our objective is to illustrate how these powerful tools can reveal the molecular mechanisms that underlie carbohydrate-mediated signal transduction.
doi_str_mv	10.1039/c3cs60097a
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source	Royal Society of Chemistry
subjects	Bearing Biomimetic Materials - chemistry Biomimetic Materials - metabolism Carbohydrates Cellular communication Derivatives Glycan Glycopolymers Humans Molecular Probes - chemistry Molecular Probes - metabolism Mucins - chemistry Mucins - metabolism Polymers Polymers - chemistry polysaccharides Polysaccharides - chemistry Polysaccharides - metabolism Receptors, Cell Surface - chemistry Receptors, Cell Surface - metabolism Reproduction Signal Transduction
title	Glycopolymer probes of signal transduction
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