Sulforaphane inhibits mammary adipogenesis by targeting adipose mesenchymal stem cells

It is now well accepted that tumor cells actively communicate with the tumor microenvironment (e.g., adipocytes) leading to the progression of breast cancer and other malignancies. It is also known that adipose mesenchymal stem cells (MSCs) have the ability to differentiate into mature adipocytes an...

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Bibliographic Details
Published in:Breast cancer research and treatment 2013-09, Vol.141 (2), p.317-324
Main Authors: Li, Qinglin, Xia, Jixiang, Yao, Yuan, Gong, Da-wei, Shi, Hongfei, Zhou, Qun
Format: Article
Language:English
Subjects:
Adipocytes
Adipocytes - cytology
Adipocytes - drug effects
Adipocytes - metabolism
Adipogenesis - drug effects
Animals
Biological and medical sciences
Breast cancer
Breast Neoplasms - metabolism
Breast Neoplasms - pathology
Brief Report
Cancer research
Cancer therapies
Cell Communication - drug effects
Cell Differentiation - drug effects
Cell Line
Cell Movement - drug effects
Cell Transformation, Neoplastic - drug effects
Coculture Techniques
Culture Media, Conditioned
Cytokines - metabolism
Development and progression
Disease Models, Animal
Disease prevention
Female
Gynecology. Andrology. Obstetrics
Heterografts
Humans
Isothiocyanates - pharmacology
Mammary gland diseases
Mammary Glands, Human - drug effects
Mammary Glands, Human - metabolism
Medical sciences
Medicine
Medicine & Public Health
Mesenchymal Stem Cells - cytology
Mesenchymal Stem Cells - drug effects
Mice
Multiple tumors. Solid tumors. Tumors in childhood (general aspects)
Oncology
Pharmacology
Signal transduction
Stem cells
Tumors
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Summary:It is now well accepted that tumor cells actively communicate with the tumor microenvironment (e.g., adipocytes) leading to the progression of breast cancer and other malignancies. It is also known that adipose mesenchymal stem cells (MSCs) have the ability to differentiate into mature adipocytes and initiate cytokine signaling within the tumor microenvironment. Here, we examine the role of MSC-differentiated adipocytes on breast cancer cell migration, and test the effects of sulforaphane (SFN, a dietary chemoprevention agent) on adipocyte–breast cancer cell interaction. Our results demonstrate that SFN promotes MSC self-renewal and inhibits adipogenic differentiation. Subsequently, SFN treatment of adipocytes considerably hinders cytokine communication with breast cancer cells, thereby decreasing breast cancer cell migration and tumor formation.
ISSN:0167-6806
1573-7217
DOI:10.1007/s10549-013-2672-1