Toenail iron, genetic determinants of iron status, and the risk of glioma

Purpose: Iron is essential for oxygen transport and oxidative metabolism; however, elevated iron stores can trigger overproduction of reactive oxygen species and induce DNA damage. Little is known about the association between body iron stores and glioma risk. This study examined the associations of...

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Bibliographic Details
Published in:Cancer causes & control 2013-12, Vol.24 (12), p.2051-2058
Main Authors: Anic, Gabriella M., Madden, Melissa H., Thompson, Reid C., Nabors, L. Burton, Olson, Jeffrey J., LaRocca, Renato V., Browning, James E., Brockman, John D., Forsyth, Peter A., Egan, Kathleen M.
Format: Article
Language:English
Subjects:
Adolescent
Adult
Aged
Aged, 80 and over
Alleles
Biomedical and Life Sciences
Biomedicine
Brain cancer
Brain Neoplasms - blood
Brain Neoplasms - epidemiology
Brain Neoplasms - genetics
Brain research
Cancer
Cancer Research
Case-Control Studies
Dietary iron
DNA damage
DNA, Neoplasm - genetics
Epidemiology
Female
Ferritins - blood
Follow-Up Studies
Genetic testing
Genotype
Genotypes
Glioma
Glioma - blood
Glioma - epidemiology
Glioma - genetics
Hematology
Humans
Iron
Iron - metabolism
Iron, Dietary
Male
Medical genetics
Metabolism
Middle Aged
Nails - chemistry
Neoplasm Grading
Neoplasm Proteins - genetics
Neurosurgery
Oncology
Original Paper
P values
Polymerase Chain Reaction
Prognosis
Public Health
Risk Factors
Survival Rate
Toenails
Tumors
Young Adult
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Summary:Purpose: Iron is essential for oxygen transport and oxidative metabolism; however, elevated iron stores can trigger overproduction of reactive oxygen species and induce DNA damage. Little is known about the association between body iron stores and glioma risk. This study examined the associations of iron levels measured in toenails and genetic variants linked to body iron stores with risk of glioma in a clinic-based case–control study. Methods: Samples were collected a median of 24 days following glioma diagnosis in the cases (10th–90th percentile, range: 10–44 days). Nail iron levels were measured in 300 cases and 300 controls using neutron activation analysis. A total of 24 genetic variants associated with iron status were genotyped in 622 cases and 628 controls. Logistic regression was used to estimate odds ratios (OR) and 95 % confidence intervals (CI) for glioma risk according to toenail iron and the examined genotypes. Results: No association was observed between toenail iron and glioma risk when restricting to cases with nails collected within ∼3 weeks of diagnosis (OR = 0.93; 95 % CI 0.46, 1.87 comparing those with high (≥14 μ/g) vs. low (
ISSN:0957-5243
1573-7225
DOI:10.1007/s10552-013-0281-2