Pro-adrenomedullin, pro-endothelin-1, procalcitonin, C-reactive protein and mortality risk in critically ill children: a prospective study

We tested the hypothesis that higher mid-regional pro-adrenomedullin (MR-proADM), carboxy-terminal pro-endothelin-1 (CT-proET-1), procalcitonin (PCT) and C-reactive protein (CRP) plasma concentrations would be associated with increased prediction of mortality risk scores. Prospective observational s...

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Published in:Critical care (London, England) England), 2013-10, Vol.17 (5), p.R240-R240, Article R240
Main Authors: Rey, Corsino, García-Hernández, Irene, Concha, Andrés, Martínez-Camblor, Pablo, Botrán, Marta, Medina, Alberto, Prieto, Belén, López-Herce, Jesús
Format: Article
Language:English
Subjects:
Adrenomedullin - blood
Biological markers
Biomarkers - blood
C-reactive protein
C-Reactive Protein - metabolism
Calcitonin
Calcitonin - blood
Calcitonin Gene-Related Peptide
Child
Child, Preschool
Comparative analysis
Critical Illness - mortality
Critically ill children
Endothelin
Endothelin-1 - blood
Female
Humans
Male
Measurement
Prognosis
Prospective Studies
Protein Precursors - blood
Risk
Sensitivity and Specificity
Sepsis
Spain - epidemiology
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Summary:We tested the hypothesis that higher mid-regional pro-adrenomedullin (MR-proADM), carboxy-terminal pro-endothelin-1 (CT-proET-1), procalcitonin (PCT) and C-reactive protein (CRP) plasma concentrations would be associated with increased prediction of mortality risk scores. Prospective observational study set in two pediatric intensive care units (PICUs). Two-hundred-thirty-eight patients were included. MR-proADM, CT-proET-1, PCT and CRP levels were compared between children with PRISM III and PIM 2 > p75 (Group A; n = 33) and the rest (Group B; n = 205). Median (range) MR-proADM levels were 1.39 nmol/L (0.52-12.67) in group A versus 0.54 (0.15-3.85) in group B (P  2.05 ng/mL had 80% sensitivity and specificity. In critically ill children, high levels of MR-proADM, CT-proET-1 and PCT were associated with increased prediction of mortality risk scores. MR-proADM, CT-proET-1 and PCT concentrations higher than 0.80 nmol/L, 123 pmol/L and 2 ng/mL, respectively, could be used by clinicians to identify critically ill children at higher prediction of risk death scores.
ISSN:1364-8535
1466-609X
1364-8535
DOI:10.1186/cc13064