Common variation contributes to the genetic architecture of social communication traits

Social communication difficulties represent an autistic trait that is highly heritable and persistent during the course of development. However, little is known about the underlying genetic architecture of this phenotype. We performed a genome-wide association study on parent-reported social communi...

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Bibliographic Details
Published in:Molecular autism 2013-09, Vol.4 (1), p.34-34, Article 34
Main Authors: St Pourcain, Beate, Whitehouse, Andrew J O, Ang, Wei Q, Warrington, Nicole M, Glessner, Joseph T, Wang, Kai, Timpson, Nicholas J, Evans, David M, Kemp, John P, Ring, Susan M, McArdle, Wendy L, Golding, Jean, Hakonarson, Hakon, Pennell, Craig E, Smith, George Davey
Format: Article
Language:English
Subjects:
Autistic children
Genes
Genetic aspects
Genetic research
Genome-wide association studies
Ligases
Phenotype
Protein binding
Single nucleotide polymorphisms
Social aspects
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Summary:Social communication difficulties represent an autistic trait that is highly heritable and persistent during the course of development. However, little is known about the underlying genetic architecture of this phenotype. We performed a genome-wide association study on parent-reported social communication problems using items of the children's communication checklist (age 10 to 11 years) studying single and/or joint marker effects. Analyses were conducted in a large UK population-based birth cohort (Avon Longitudinal Study of Parents and their Children, ALSPAC, N = 5,584) and followed-up within a sample of children with comparable measures from Western Australia (RAINE, N = 1364). Two of our seven independent top signals (P-discovery
ISSN:2040-2392
2040-2392
DOI:10.1186/2040-2392-4-34