Mixed Lineage Kinase-c-Jun N-Terminal Kinase Axis: A Potential Therapeutic Target in Cancer

Mixed lineage kinases (MLKs) are members of the mitogen-activated protein kinase kinase kinase (MAP3K) family and are reported to activate MAP kinase pathways. There have been at least 9 members of the MLK family identified to date, although the physiological functions of all the family members are...

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Published in:Genes & cancer 2013-09, Vol.4 (9-10), p.334-341
Main Authors: Rana, Ajay, Rana, Basabi, Mishra, Rajakishore, Sondarva, Gautam, Rangasamy, Velusamy, Das, Subhasis, Viswakarma, Navin, Kanthasamy, Anumantha
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container_end_page 341
container_issue 9-10
container_start_page 334
container_title Genes & cancer
container_volume 4
creator Rana, Ajay
Rana, Basabi
Mishra, Rajakishore
Sondarva, Gautam
Rangasamy, Velusamy
Das, Subhasis
Viswakarma, Navin
Kanthasamy, Anumantha
description Mixed lineage kinases (MLKs) are members of the mitogen-activated protein kinase kinase kinase (MAP3K) family and are reported to activate MAP kinase pathways. There have been at least 9 members of the MLK family identified to date, although the physiological functions of all the family members are yet unknown. However, MLKs in general have been implicated in neurodegenerative diseases, including Parkinson and Alzheimer diseases. Recent reports suggest that some of the MLK members could play a role in cancer via modulating cell migration, invasion, cell cycle, and apoptosis. This review article will first describe the biology of MLK members and then discuss the current progress that relates to their functions in cancer.
doi_str_mv 10.1177/1947601913485415
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title Mixed Lineage Kinase-c-Jun N-Terminal Kinase Axis: A Potential Therapeutic Target in Cancer
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