Amygdala and whole-brain activity to emotional faces distinguishes major depressive disorder and bipolar disorder

Objectives It can be clinically difficult to distinguish depressed individuals with bipolar disorder (BD) and major depressive disorder (MDD). To examine potential biomarkers of difference between the two disorders, the current study examined differences in the functioning of emotion‐processing neur...

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Bibliographic Details
Published in:Bipolar disorders 2013-11, Vol.15 (7), p.741-752
Main Authors: Fournier, Jay C, Keener, Matthew T, Almeida, Jorge, Kronhaus, Dina M, Phillips, Mary L
Format: Article
Language:English
Subjects:
Adult
amygdala
Amygdala - blood supply
Amygdala - pathology
Analysis of Variance
bipolar disorder
Bipolar Disorder - diagnosis
Brain - blood supply
Brain - pathology
brain imaging
Depressive Disorder, Major - diagnosis
emotion processing
Emotions - physiology
Facial Expression
Female
Humans
Image Processing, Computer-Assisted
Magnetic Resonance Imaging
major depressive disorder
Male
Oxygen - blood
Pattern Recognition, Visual
Photic Stimulation
whole brain
Young Adult
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Summary:Objectives It can be clinically difficult to distinguish depressed individuals with bipolar disorder (BD) and major depressive disorder (MDD). To examine potential biomarkers of difference between the two disorders, the current study examined differences in the functioning of emotion‐processing neural regions during a dynamic emotional faces task. Methods During functional magnetic resonance imaging, healthy control adults (HC) (n = 29) and depressed adults with MDD (n = 30) and BD (n = 22) performed an implicit emotional‐faces task in which they identified a color label superimposed on neutral faces that dynamically morphed into one of four emotional faces (angry, fearful, sad, happy). We compared neural activation between the groups in an amygdala region‐of‐interest and at the whole‐brain level. Results Adults with MDD showed significantly greater activity than adults with BD in the left amygdala to the anger condition (p = 0.01). Results of whole‐brain analyses (at p 
ISSN:1398-5647
1399-5618
DOI:10.1111/bdi.12106