Essential role of axonal VGSC inactivation in time-dependent deceleration and unreliability of spike propagation at cerebellar Purkinje cells

The output of the neuronal digital spikes is fulfilled by axonal propagation and synaptic transmission to influence postsynaptic cells. Similar to synaptic transmission, spike propagation on the axon is not secure, especially in cerebellar Purkinje cells whose spiking rate is high. The characteristi...

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Bibliographic Details
Published in:Molecular brain 2014-01, Vol.7 (1), p.1-1, Article 1
Main Authors: Yang, Zhilai, Gu, Erwei, Lu, Xianfu, Wang, Jin-Hui
Format: Article
Language:English
Subjects:
Action Potentials - drug effects
Action Potentials - physiology
Animals
Axons
Axons - drug effects
Axons - physiology
Cerebellum - cytology
Cnidarian Venoms - toxicity
Hypotheses
Ion Channel Gating - drug effects
Ion Channel Gating - physiology
Medical research
Propagation
Purkinje Cells - drug effects
Purkinje Cells - physiology
Rats
Rats, Wistar
Standard deviation
Time Factors
Voltage-Gated Sodium Channels - metabolism
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Summary:The output of the neuronal digital spikes is fulfilled by axonal propagation and synaptic transmission to influence postsynaptic cells. Similar to synaptic transmission, spike propagation on the axon is not secure, especially in cerebellar Purkinje cells whose spiking rate is high. The characteristics, mechanisms and physiological impacts of propagation deceleration and infidelity remain elusive. The spike propagation is presumably initiated by local currents that raise membrane potential to the threshold of activating voltage-gated sodium channels (VGSC). We have investigated the natures of spike propagation and the role of VGSCs in this process by recording spikes simultaneously on the somata and axonal terminals of Purkinje cells in cerebellar slices. The velocity and fidelity of spike propagation decreased during long-lasting spikes, to which the velocity change was more sensitive than fidelity change. These time-dependent deceleration and infidelity of spike propagation were improved by facilitating axonal VGSC reactivation, and worsen by intensifying VGSC inactivation. Our studies indicate that the functional status of axonal VGSCs is essential to influencing the velocity and fidelity of spike propagation.
ISSN:1756-6606
1756-6606
DOI:10.1186/1756-6606-7-1