Recent Developments in the Catalytic, Asymmetric Construction of Pyrroloindolines Bearing All-Carbon Quaternary Stereocenters

Pyrroloindoline alkaloids constitute a large family of natural products that has inspired the development of an impressive array of new reactions to prepare the key heterocyclic motif. This synopsis will address catalytic, asymmetric reactions developed to synthesize pyrroloindolines bearing C3a all...

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Bibliographic Details
Published in:Journal of organic chemistry 2013-12, Vol.78 (24), p.12314-12320
Main Authors: Repka, Lindsay M, Reisman, Sarah E
Format: Article
Language:English
Subjects:
alkaloids
Carbon - chemistry
Catalysis
chemical reactions
chemical structure
Indoles - chemical synthesis
Indoles - chemistry
Molecular Structure
organic chemistry
Organometallic Compounds - chemistry
Pyrroles - chemical synthesis
Pyrroles - chemistry
Stereoisomerism
Transition Elements - chemistry
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Summary:Pyrroloindoline alkaloids constitute a large family of natural products that has inspired the development of an impressive array of new reactions to prepare the key heterocyclic motif. This synopsis will address catalytic, asymmetric reactions developed to synthesize pyrroloindolines bearing C3a all-carbon quaternary stereocenters. The methods described herein include both transition-metal-catalyzed and organocatalyzed reactions that have been demonstrated to be suitable for the synthesis of the pyrroloindoline framework.
ISSN:0022-3263
1520-6904
1520-6904
DOI:10.1021/jo4017953