Respiratory viral infection in neonatal piglets causes marked microglia activation in the hippocampus and deficits in spatial learning

Environmental insults during sensitive periods can affect hippocampal development and function, but little is known about peripheral infection, especially in humans and other animals whose brain is gyrencephalic and experiences major perinatal growth. Using a piglet model, the present study showed t...

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Bibliographic Details
Published in:The Journal of neuroscience 2014-02, Vol.34 (6), p.2120-2129
Main Authors: Elmore, Monica R P, Burton, Michael D, Conrad, Matthew S, Rytych, Jennifer L, Van Alstine, William G, Johnson, Rodney W
Format: Article
Language:English
Subjects:
Animals
Animals, Newborn
Female
Hippocampus - metabolism
Hippocampus - virology
Male
Maze Learning - physiology
Microglia - metabolism
Microglia - virology
Porcine Reproductive and Respiratory Syndrome - metabolism
Porcine Reproductive and Respiratory Syndrome - pathology
Porcine respiratory and reproductive syndrome virus
Porcine respiratory and reproductive syndrome virus - physiology
Spatial Behavior - physiology
Swine
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Summary:Environmental insults during sensitive periods can affect hippocampal development and function, but little is known about peripheral infection, especially in humans and other animals whose brain is gyrencephalic and experiences major perinatal growth. Using a piglet model, the present study showed that inoculation on postnatal day 7 with the porcine reproductive and respiratory syndrome virus (PRRSV) caused microglial activation within the hippocampus with 82% and 43% of isolated microglia being MHC II(+) 13 and 20 d after inoculation, respectively. In control piglets,
ISSN:0270-6474
1529-2401
DOI:10.1523/JNEUROSCI.2180-13.2014