Comparative absorption of curcumin formulations

BACKGROUND: The potential health benefits of curcumin are limited by its poor solubility, low absorption from the gut, rapid metabolism and rapid systemic elimination. The purpose of this study was the comparative measurement of the increases in levels of curcuminoids (curcumin, demethoxycurcumin, b...

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Published in:Nutrition journal 2014-01, Vol.13 (1), p.11-11, Article 11
Main Authors: Jäger, Ralf, Lowery, Ryan P, Calvanese, Allison V, Joy, Jordan M, Purpura, Martin, Wilson, Jacob M
Format: Article
Language:English
Subjects:
absorption
Administration, Oral
Adult
antioxidants
Aqueous solutions
blood
Cell cycle
Cellulose
Colleges & universities
Comparative analysis
curcumin
Curcumin - administration & dosage
Curcumin - analogs & derivatives
Diarylheptanoids
digestive system
Enzymes
Female
Health aspects
Health insurance
Humans
intestinal absorption
Intestinal Absorption - physiology
Male
Measurement
metabolism
Metabolites
Methods
Nanocrystals
oils
oral administration
Physical fitness
Plasma
Solubility
Surfactants
turmeric
volunteers
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container_issue 1
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container_title Nutrition journal
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creator Jäger, Ralf
Lowery, Ryan P
Calvanese, Allison V
Joy, Jordan M
Purpura, Martin
Wilson, Jacob M
description BACKGROUND: The potential health benefits of curcumin are limited by its poor solubility, low absorption from the gut, rapid metabolism and rapid systemic elimination. The purpose of this study was the comparative measurement of the increases in levels of curcuminoids (curcumin, demethoxycurcumin, bisdemethoxycurcumin) and the metabolite tetrahydrocurcumin after oral administration of three different curcumin formulations in comparison to unformulated standard. METHODS: The relative absorption of a curcumin phytosome formulation (CP), a formulation with volatile oils of turmeric rhizome (CTR) and a formulation of curcumin with a combination of hydrophilic carrier, cellulosic derivatives and natural antioxidants (CHC) in comparison to a standardized curcumin mixture (CS) was investigated in a randomized, double-blind, crossover human study in healthy volunteers. Samples were analyzed by HPLC-MS/MS. RESULTS: Total curcuminoids appearance in the blood was 1.3-fold higher for CTR and 7.9-fold higher for CP in comparison to unformulated CS. CHC showed a 45.9-fold higher absorption over CS and significantly improved absorption over CP (5.8-fold) and CTR (34.9-fold, all p 
doi_str_mv 10.1186/1475-2891-13-11
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The purpose of this study was the comparative measurement of the increases in levels of curcuminoids (curcumin, demethoxycurcumin, bisdemethoxycurcumin) and the metabolite tetrahydrocurcumin after oral administration of three different curcumin formulations in comparison to unformulated standard. METHODS: The relative absorption of a curcumin phytosome formulation (CP), a formulation with volatile oils of turmeric rhizome (CTR) and a formulation of curcumin with a combination of hydrophilic carrier, cellulosic derivatives and natural antioxidants (CHC) in comparison to a standardized curcumin mixture (CS) was investigated in a randomized, double-blind, crossover human study in healthy volunteers. Samples were analyzed by HPLC-MS/MS. RESULTS: Total curcuminoids appearance in the blood was 1.3-fold higher for CTR and 7.9-fold higher for CP in comparison to unformulated CS. CHC showed a 45.9-fold higher absorption over CS and significantly improved absorption over CP (5.8-fold) and CTR (34.9-fold, all p &lt; 0.001). CONCLUSION: A formulation of curcumin with a combination of hydrophilic carrier, cellulosic derivatives and natural antioxidants significantly increases curcuminoid appearance in the blood in comparison to unformulated standard curcumin CS, CTR and CP.</description><identifier>ISSN: 1475-2891</identifier><identifier>EISSN: 1475-2891</identifier><identifier>DOI: 10.1186/1475-2891-13-11</identifier><identifier>PMID: 24461029</identifier><language>eng</language><publisher>England: Springer-Verlag</publisher><subject>absorption ; Administration, Oral ; Adult ; antioxidants ; Aqueous solutions ; blood ; Cell cycle ; Cellulose ; Colleges &amp; universities ; Comparative analysis ; curcumin ; Curcumin - administration &amp; dosage ; Curcumin - analogs &amp; derivatives ; Diarylheptanoids ; digestive system ; Enzymes ; Female ; Health aspects ; Health insurance ; Humans ; intestinal absorption ; Intestinal Absorption - physiology ; Male ; Measurement ; metabolism ; Metabolites ; Methods ; Nanocrystals ; oils ; oral administration ; Physical fitness ; Plasma ; Solubility ; Surfactants ; turmeric ; volunteers</subject><ispartof>Nutrition journal, 2014-01, Vol.13 (1), p.11-11, Article 11</ispartof><rights>COPYRIGHT 2014 BioMed Central Ltd.</rights><rights>2014 Jäger et al.; licensee BioMed Central Ltd. 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The purpose of this study was the comparative measurement of the increases in levels of curcuminoids (curcumin, demethoxycurcumin, bisdemethoxycurcumin) and the metabolite tetrahydrocurcumin after oral administration of three different curcumin formulations in comparison to unformulated standard. METHODS: The relative absorption of a curcumin phytosome formulation (CP), a formulation with volatile oils of turmeric rhizome (CTR) and a formulation of curcumin with a combination of hydrophilic carrier, cellulosic derivatives and natural antioxidants (CHC) in comparison to a standardized curcumin mixture (CS) was investigated in a randomized, double-blind, crossover human study in healthy volunteers. Samples were analyzed by HPLC-MS/MS. RESULTS: Total curcuminoids appearance in the blood was 1.3-fold higher for CTR and 7.9-fold higher for CP in comparison to unformulated CS. 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CHC showed a 45.9-fold higher absorption over CS and significantly improved absorption over CP (5.8-fold) and CTR (34.9-fold, all p &lt; 0.001). CONCLUSION: A formulation of curcumin with a combination of hydrophilic carrier, cellulosic derivatives and natural antioxidants significantly increases curcuminoid appearance in the blood in comparison to unformulated standard curcumin CS, CTR and CP.</abstract><cop>England</cop><pub>Springer-Verlag</pub><pmid>24461029</pmid><doi>10.1186/1475-2891-13-11</doi><tpages>1</tpages><oa>free_for_read</oa></addata></record>
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subjects absorption
Administration, Oral
Adult
antioxidants
Aqueous solutions
blood
Cell cycle
Cellulose
Colleges & universities
Comparative analysis
curcumin
Curcumin - administration & dosage
Curcumin - analogs & derivatives
Diarylheptanoids
digestive system
Enzymes
Female
Health aspects
Health insurance
Humans
intestinal absorption
Intestinal Absorption - physiology
Male
Measurement
metabolism
Metabolites
Methods
Nanocrystals
oils
oral administration
Physical fitness
Plasma
Solubility
Surfactants
turmeric
volunteers
title Comparative absorption of curcumin formulations
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