Signaling regulated endocytosis and exocytosis lead to mating pheromone concentration dependent morphologies in yeast

► Developed a mathematical model of membrane deformation coupled to cellular membrane signaling. ► Signaling mediated membrane velocity captures yeast budding and shmoo morphologies. ► Yeast mating projection morphology is inversely related to pheromone concentration. ► Morphology is the result of s...

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Bibliographic Details
Published in:FEBS letters 2012-11, Vol.586 (23), p.4208-4214
Main Authors: Chou, Ching-Shan, Moore, Travis I., Chang, Steven D., Nie, Qing, Yi, Tau-Mu
Format: Article
Language:English
Subjects:
Cell morphology
Cell polarization
Deforming membrane
Endocytosis - physiology
Exocytosis - physiology
Membrane dynamics
Models, Theoretical
Pheromones - metabolism
Saccharomyces cerevisiae
Saccharomyces cerevisiae - metabolism
Saccharomyces cerevisiae - physiology
Signaling mediated endocytosis
Yeast mating
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Summary:► Developed a mathematical model of membrane deformation coupled to cellular membrane signaling. ► Signaling mediated membrane velocity captures yeast budding and shmoo morphologies. ► Yeast mating projection morphology is inversely related to pheromone concentration. ► Morphology is the result of signaling induced balance of endocytosis and exocytosis. Polarized cell morphogenesis requires actin cytoskeleton rearrangement for polarized transport of proteins, organelles and secretory vesicles, which fundamentally underlies cell differentiation and behavior. During yeast mating, Saccharomyces cerevisiae responds to extracellular pheromone gradients by extending polarized projections, which are likely maintained through vesicle transport to (exocytosis) and from (endocytosis) the membrane. We experimentally demonstrate that the projection morphology is pheromone concentration-dependent, and propose the underlying mechanism through mathematical modeling. The inclusion of membrane flux and dynamically evolving cell boundary into our yeast mating signaling model shows good agreement with experimental measurements, and provides a plausible explanation for pheromone-induced cell morphology.
ISSN:0014-5793
1873-3468
DOI:10.1016/j.febslet.2012.10.024