Objectively measured sleep duration and hyperglycemia in pregnancy

• Published in: Sleep medicine 2014-01, Vol.15 (1), p.51-55
• Main Authors: Herring, Sharon J, Nelson, Deborah B, Pien, Grace W, Homko, Carol, Goetzl, Laura M, Davey, Adam, Foster, Gary D
• Format: Article
• Language: English
• Subjects: Actigraphy; Adult; Body Mass Index; Daytime sleep duration; Diabetes, Gestational; Disorders of Excessive Somnolence - complications; Female; Gestational diabetes; Glucose Tolerance Test; Humans; Hyperglycemia; Hyperglycemia - complications; Nap frequency; Neurology; Nighttime sleep duration; Poverty; Pregnancy; Pregnancy Complications; Prospective Studies; Risk Assessment; Sleep; Sleep Medicine; Sleep Wake Disorders - complications; Urban Population; Young Adult
• ISSN: 1389-9457; 1878-5506
• DOI: 10.1016/j.sleep.2013.07.018

Abstract Objective Our primary purpose was to assess the impact of objectively measured nighttime sleep duration on gestational glucose tolerance. We additionally examined associations of objectively measured daytime sleep duration and nap frequency on maternal glycemic control. Methods Sixty-three urban, low-income, pregnant women wore wrist actigraphs for an average of 6 full days in mid-pregnancy prior to screening for hyperglycemia using the 1-h oral glucose tolerance test (OGTT). Correlations of nighttime and daytime sleep durations with 1-h OGTT values were analyzed. Multivariable logistic regression was used to evaluate independent associations between sleep parameters and hyperglycemia, defined as 1-h OGTT values ⩾130 mg/dL. Results Mean nighttime sleep duration was 6.9 ± 0.9 h which was inversely correlated with 1-h OGTT values ( r = −0.28, P = .03). Shorter nighttime sleep was associated with hyperglycemia, even after controlling for age and body mass index (adjusted odds ratio [OR], 0.2 [95% confidence interval {CI}, 0.1–0.8]). There were no associations of daytime sleep duration and nap frequency with 1-h OGTT values or hyperglycemia. Conclusions Using objective measures of maternal sleep time, we found that women with shorter nighttime sleep durations had an increased risk for gestational hyperglycemia. Larger prospective studies are needed to confirm our negative daytime sleep findings.