Fc gamma receptors in respiratory syncytial virus infections: implications for innate immunity

SUMMARY RSV infections are a major burden in infants less than 3 months of age. Newborns and infants express a distinct immune system that is largely dependent on innate immunity and passive immunity from maternal antibodies. Antibodies can regulate immune responses against viruses through interacti...

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Bibliographic Details
Published in:Reviews in medical virology 2014-01, Vol.24 (1), p.55-70
Main Authors: Jans, Jop, Vissers, Marloes, Heldens, Jacco G.M., de Jonge, Marien I., Levy, Ofer, Ferwerda, Gerben
Format: Article
Language:English
Subjects:
Antibodies, Viral - immunology
Humans
Immunity, Innate
Infant
Infant, Newborn
Receptors, IgG - immunology
Respiratory syncytial virus
Respiratory Syncytial Virus Infections - immunology
Respiratory Syncytial Virus Infections - virology
Respiratory Syncytial Virus, Human - immunology
Respiratory Syncytial Virus, Human - pathogenicity
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Summary:SUMMARY RSV infections are a major burden in infants less than 3 months of age. Newborns and infants express a distinct immune system that is largely dependent on innate immunity and passive immunity from maternal antibodies. Antibodies can regulate immune responses against viruses through interaction with Fc gamma receptors leading to enhancement or neutralization of viral infections. The mechanisms underlying the immunomodulatory effect of Fc gamma receptors on viral infections have yet to be elucidated in infants. Herein, we will discuss current knowledge of the effects of antibodies and Fc gamma receptors on infant innate immunity to RSV. A better understanding of the pathogenesis of RSV infections in young infants may provide insight into novel therapeutic strategies such as vaccination. Copyright © 2013 John Wiley & Sons, Ltd.
ISSN:1052-9276
1099-1654
DOI:10.1002/rmv.1773