Study of Effect of Salvianolic Acid B on Motor Function Recovery in Rats with Spinal Cord Injury

• Published in: BioMed research international 2014-01, Vol.2014 (2014), p.1-6
• Main Authors: Xun, Chong, Hu, Yang, Lu, Ming, Wang, Shouyu, Lv, Decheng
• Format: Article
• Language: English
• Subjects: Animals; Apoptosis; Bone surgery; Brain damage; Caffeic Acids - pharmacology; Complications and side effects; Dosage and administration; Drug therapy; Female; Gene expression; I-kappa B Proteins - metabolism; Ischemia; Kinases; Lactates - pharmacology; Molecular weight; Motor Activity - drug effects; Nerve Tissue Proteins - metabolism; Nervous system agents; NF-KappaB Inhibitor alpha; Pathogenesis; Proton Pump Inhibitors - pharmacology; Rats; Rats, Sprague-Dawley; Rodents; Spinal cord injuries; Spinal Cord Injuries - drug therapy; Spinal Cord Injuries - metabolism; Spinal Cord Injuries - pathology; Spinal Cord Injuries - physiopathology; Studies; Time Factors; Transcription Factor RelA - metabolism
• ISSN: 2314-6133; 2314-6141
• DOI: 10.1155/2014/931850

In this study effect of salvianolic acid B was observed on motor function recovery of rats with spinal cord injury. 50 rats were selected and after inducing SCI their recovery under controlled conditions was studied using Sal B and PBS (as control). Both compounds were introduced intraperitoneally in respective groups of traumatic rats at the same time intervals for 28 days. It was observed that Sal B introduced at 5  mg/kg/day resulted in better motor function recovery. BBB score was recorded which increased significantly along with the reduction in cavity area observed by bright field microscopy of tissues, that is, from 1 to 10 and from 0.20±0.05 mm2 to 0.10±0.03 mm2, in Sal B treated group, respectively, compared to PBS group. Statistical analysis was carried out using SPSS software (SPSS, Chicago, IL, USA), values were expressed as mean ± SEM, and P value