Computational model of the in vivo development of a tissue engineered vein from an implanted polymeric construct

Abstract Advances in vascular tissue engineering have been tremendous over the past 15 years, yet there remains a need to optimize current constructs to achieve vessels having true growth potential. Toward this end, it has been suggested that computational models may help hasten this process by enab...

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Bibliographic Details
Published in:Journal of biomechanics 2014-06, Vol.47 (9), p.2080-2087
Main Authors: Miller, K.S, Lee, Y.U, Naito, Y, Breuer, C.K, Humphrey, J.D
Format: Article
Language:English
Subjects:
Animals
Behavior
Biomechanics
Biomedical materials
Blood Vessel Prosthesis
Collagen
Computation
Constrained mixture theory
Construction
Deformation
Extracellular Matrix
In vivo testing
In vivo tests
Inflammation
Interposition graft
Kinetics
Mathematical models
Mechanosensing
Mice
Mice, SCID
Models, Cardiovascular
Mouse model
Physical Medicine and Rehabilitation
Polymers
Surgical implants
Tissue engineering
Tissue Scaffolds
Veins
Veins & arteries
Vena Cava, Inferior
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Summary:Abstract Advances in vascular tissue engineering have been tremendous over the past 15 years, yet there remains a need to optimize current constructs to achieve vessels having true growth potential. Toward this end, it has been suggested that computational models may help hasten this process by enabling time-efficient parametric studies that can reduce the experimental search space. In this paper, we present a first generation computational model for describing the in vivo development of a tissue engineered vein from an implanted polymeric scaffold. The model was motivated by our recent data on the evolution of mechanical properties and microstructural composition over 24 weeks in a mouse inferior vena cava interposition graft. It is shown that these data can be captured well by including both an early inflammatory-mediated and a subsequent mechano-mediated production of extracellular matrix. There remains a pressing need, however, for more data to inform the development of next generation models, particularly the precise transition from the inflammatory to the mechanobiological dominated production of matrix having functional capability.
ISSN:0021-9290
1873-2380
DOI:10.1016/j.jbiomech.2013.10.009