Association of anxiety with intracortical inhibition and descending pain modulation in chronic myofascial pain syndrome

This study aimed to answer three questions related to chronic myofascial pain syndrome (MPS): 1) Is the motor cortex excitability, as assessed by transcranial magnetic stimulation parameters (TMS), related to state-trait anxiety? 2) Does anxiety modulate corticospinal excitability changes after evok...

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Bibliographic Details
Published in:BMC neuroscience 2014-03, Vol.15 (1), p.42-42, Article 42
Main Authors: Vidor, Liliane Pinto, Torres, Iraci L S, Medeiros, Liciane Fernandes, Dussán-Sarria, Jairo Alberto, Dall'agnol, Letizzia, Deitos, Alicia, Brietzke, Aline, Laste, Gabriela, Rozisky, Joanna R, Fregni, Felipe, Caumo, Wolnei
Format: Article
Language:English
Subjects:
Adult
Aged
Analysis
Anxiety
Care and treatment
Catastrophization - physiopathology
Cerebral Cortex - physiopathology
Chronic pain
Chronic Pain - physiopathology
Development and progression
Female
Health aspects
Health sciences
Hospitals
Humans
Male
Middle Aged
Myofascial Pain Syndromes - physiopathology
Neural Inhibition
Pain
Pain Threshold
Palliative care
Patient outcomes
Post traumatic stress disorder
Psychological aspects
Risk factors
Transcranial Magnetic Stimulation
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Summary:This study aimed to answer three questions related to chronic myofascial pain syndrome (MPS): 1) Is the motor cortex excitability, as assessed by transcranial magnetic stimulation parameters (TMS), related to state-trait anxiety? 2) Does anxiety modulate corticospinal excitability changes after evoked pain by Quantitative Sensory Testing (QST)? 3) Does the state-trait anxiety predict the response to pain evoked by QST if simultaneously receiving a heterotopic stimulus [Conditional Pain Modulation (CPM)]? We included females with chronic MPS (n = 47) and healthy controls (n = 11), aged 19 to 65 years. Motor cortex excitability was assessed by TMS, and anxiety was assessed based on the State-Trait Anxiety Inventory. The disability related to pain (DRP) was assessed by the Profile of Chronic Pain scale for the Brazilian population (B:PCP:S), and the psychophysical pain measurements were measured by the QST and CPM. In patients, trait-anxiety was positively correlated to intracortical facilitation (ICF) at baseline and after QST evoked pain (β = 0.05 and β = 0.04, respectively) and negatively correlated to the cortical silent period (CSP) (β = -1.17 and β = -1.23, respectively) (P
ISSN:1471-2202
1471-2202
DOI:10.1186/1471-2202-15-42