Association of anxiety with intracortical inhibition and descending pain modulation in chronic myofascial pain syndrome

This study aimed to answer three questions related to chronic myofascial pain syndrome (MPS): 1) Is the motor cortex excitability, as assessed by transcranial magnetic stimulation parameters (TMS), related to state-trait anxiety? 2) Does anxiety modulate corticospinal excitability changes after evok...

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Published in:BMC neuroscience 2014-03, Vol.15 (1), p.42-42, Article 42
Main Authors: Vidor, Liliane Pinto, Torres, Iraci L S, Medeiros, Liciane Fernandes, Dussán-Sarria, Jairo Alberto, Dall'agnol, Letizzia, Deitos, Alicia, Brietzke, Aline, Laste, Gabriela, Rozisky, Joanna R, Fregni, Felipe, Caumo, Wolnei
Format: Article
Language:English
Subjects:
Adult
Aged
Analysis
Anxiety
Care and treatment
Catastrophization - physiopathology
Cerebral Cortex - physiopathology
Chronic pain
Chronic Pain - physiopathology
Development and progression
Female
Health aspects
Health sciences
Hospitals
Humans
Male
Middle Aged
Myofascial Pain Syndromes - physiopathology
Neural Inhibition
Pain
Pain Threshold
Palliative care
Patient outcomes
Post traumatic stress disorder
Psychological aspects
Risk factors
Transcranial Magnetic Stimulation
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creator Vidor, Liliane Pinto
Torres, Iraci L S
Medeiros, Liciane Fernandes
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Laste, Gabriela
Rozisky, Joanna R
Fregni, Felipe
Caumo, Wolnei
description This study aimed to answer three questions related to chronic myofascial pain syndrome (MPS): 1) Is the motor cortex excitability, as assessed by transcranial magnetic stimulation parameters (TMS), related to state-trait anxiety? 2) Does anxiety modulate corticospinal excitability changes after evoked pain by Quantitative Sensory Testing (QST)? 3) Does the state-trait anxiety predict the response to pain evoked by QST if simultaneously receiving a heterotopic stimulus [Conditional Pain Modulation (CPM)]? We included females with chronic MPS (n = 47) and healthy controls (n = 11), aged 19 to 65 years. Motor cortex excitability was assessed by TMS, and anxiety was assessed based on the State-Trait Anxiety Inventory. The disability related to pain (DRP) was assessed by the Profile of Chronic Pain scale for the Brazilian population (B:PCP:S), and the psychophysical pain measurements were measured by the QST and CPM. In patients, trait-anxiety was positively correlated to intracortical facilitation (ICF) at baseline and after QST evoked pain (β = 0.05 and β = 0.04, respectively) and negatively correlated to the cortical silent period (CSP) (β = -1.17 and β = -1.23, respectively) (P
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We included females with chronic MPS (n = 47) and healthy controls (n = 11), aged 19 to 65 years. Motor cortex excitability was assessed by TMS, and anxiety was assessed based on the State-Trait Anxiety Inventory. The disability related to pain (DRP) was assessed by the Profile of Chronic Pain scale for the Brazilian population (B:PCP:S), and the psychophysical pain measurements were measured by the QST and CPM. In patients, trait-anxiety was positively correlated to intracortical facilitation (ICF) at baseline and after QST evoked pain (β = 0.05 and β = 0.04, respectively) and negatively correlated to the cortical silent period (CSP) (β = -1.17 and β = -1.23, respectively) (P &lt;0.05 for all comparisons). After QST evoked pain, the DRP was positively correlated to ICF (β = 0.02) (P &lt; 0.05). Pain scores during CPM were positively correlated with trait-anxiety when it was concurrently with high DRP (β = 0.39; P = 0.02). Controls' cortical excitability remained unchanged after QST. 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This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.</rights><rights>Copyright © 2014 Vidor et al.; licensee BioMed Central Ltd. 2014 Vidor et al.; licensee BioMed Central Ltd.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c521t-e37c089c9bc3627849d45a89bd6366563332387dfe930015553ee596f74e5cd43</citedby><cites>FETCH-LOGICAL-c521t-e37c089c9bc3627849d45a89bd6366563332387dfe930015553ee596f74e5cd43</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3995110/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.proquest.com/docview/1518540263?pq-origsite=primo$$EHTML$$P50$$Gproquest$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,885,25753,27924,27925,37012,37013,44590,53791,53793</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/24645677$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Vidor, Liliane Pinto</creatorcontrib><creatorcontrib>Torres, Iraci L S</creatorcontrib><creatorcontrib>Medeiros, Liciane Fernandes</creatorcontrib><creatorcontrib>Dussán-Sarria, Jairo Alberto</creatorcontrib><creatorcontrib>Dall'agnol, Letizzia</creatorcontrib><creatorcontrib>Deitos, Alicia</creatorcontrib><creatorcontrib>Brietzke, Aline</creatorcontrib><creatorcontrib>Laste, Gabriela</creatorcontrib><creatorcontrib>Rozisky, Joanna R</creatorcontrib><creatorcontrib>Fregni, Felipe</creatorcontrib><creatorcontrib>Caumo, Wolnei</creatorcontrib><title>Association of anxiety with intracortical inhibition and descending pain modulation in chronic myofascial pain syndrome</title><title>BMC neuroscience</title><addtitle>BMC Neurosci</addtitle><description>This study aimed to answer three questions related to chronic myofascial pain syndrome (MPS): 1) Is the motor cortex excitability, as assessed by transcranial magnetic stimulation parameters (TMS), related to state-trait anxiety? 2) Does anxiety modulate corticospinal excitability changes after evoked pain by Quantitative Sensory Testing (QST)? 3) Does the state-trait anxiety predict the response to pain evoked by QST if simultaneously receiving a heterotopic stimulus [Conditional Pain Modulation (CPM)]? 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subjects Adult
Aged
Analysis
Anxiety
Care and treatment
Catastrophization - physiopathology
Cerebral Cortex - physiopathology
Chronic pain
Chronic Pain - physiopathology
Development and progression
Female
Health aspects
Health sciences
Hospitals
Humans
Male
Middle Aged
Myofascial Pain Syndromes - physiopathology
Neural Inhibition
Pain
Pain Threshold
Palliative care
Patient outcomes
Post traumatic stress disorder
Psychological aspects
Risk factors
Transcranial Magnetic Stimulation
title Association of anxiety with intracortical inhibition and descending pain modulation in chronic myofascial pain syndrome
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