Meta-analyses between 18 candidate genetic markers and overweight/obesity

• Published in: Diagnostic pathology 2014-03, Vol.9 (1), p.56-56, Article 56
• Main Authors: Tang, Linlin, Ye, Huadan, Hong, Qingxiao, Chen, Fei, Wang, Qinwen, Xu, Leiting, Bu, Shizhong, Liu, Qiong, Ye, Meng, Wang, Dao Wen, Mai, Yifeng, Duan, Shiwei
• Format: Article
• Language: English
• Subjects: Adaptor Proteins, Signal Transducing - genetics; Analysis; Apoptosis Regulatory Proteins - genetics; Genes; Genetic aspects; Genetic markers; Genetic Predisposition to Disease - genetics; Humans; Membrane Proteins - genetics; Mutation; Obesity; Obesity - genetics; Overweight - genetics; Polymorphism, Single Nucleotide; Studies
• ISSN: 1746-1596; 1746-1596
• DOI: 10.1186/1746-1596-9-56

The goal of our study is to investigate the associations between 18 candidate genetic markers and overweight/obesity. A total of 72 eligible articles were retrieved from literature databases including PubMed, Embase, SpingerLink, Web of Science, Chinese National Knowledge Infrastructure (CNKI), and Wanfang. Meta-analyses of 18 genetic markers among 56,738 controls and 48,148 overweight/obese persons were done by Review Manager 5.0. Our results showed that SH2B1 rs7498665 polymorphism was significantly associated with the risk of overweight/obesity (overall odds ratio (OR) = 1.21, 95% confidence interval (CI) = 1.09-1.34, P = 0.0004). Increased risk of overweight/obesity was also observed in FAIM2 rs7138803 polymorphism (overall OR = 1.11, 95% CI = 1.01-1.22, P = 0.04). Our meta-analyses have shown the important role of 2 polymorphisms (SH2B1 rs7498665 and FAIM2 rs7138803) in the development of overweight/obesity. This study highlighted the importance of above two candidate genes (SH2B1 and FAIM2) in the risk of overweight/obesity. The virtual slide(s) for this article can be found here: http://www.diagnosticpathology.diagnomx.eu/vs/2785487401176182.