Loading…

Correlation between Urothelial Differentiation and Sensory Proteins P2X3, P2X5, TRPV1, and TRPV4 in Normal Urothelium and Papillary Carcinoma of Human Bladder

Terminal differentiation of urothelium is a prerequisite for blood-urine barrier formation and enables normal sensory function of the urinary bladder. In this study, urothelial differentiation of normal human urothelium and of low and high grade papillary urothelial carcinomas was correlated with th...

Full description

Saved in:
Bibliographic Details
Published in:BioMed research international 2014-01, Vol.2014 (2014), p.1-9
Main Authors: Sterle, Igor, Zupančič, Daša, Romih, Rok
Format: Article
Language:English
Subjects:
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
cited_by cdi_FETCH-LOGICAL-c527t-fe9959250a6e4b7fe3bd00ba1553f077eb61fd6e95b60da2d34fe6fbafc9ab173
cites cdi_FETCH-LOGICAL-c527t-fe9959250a6e4b7fe3bd00ba1553f077eb61fd6e95b60da2d34fe6fbafc9ab173
container_end_page 9
container_issue 2014
container_start_page 1
container_title BioMed research international
container_volume 2014
creator Sterle, Igor
Zupančič, Daša
Romih, Rok
description Terminal differentiation of urothelium is a prerequisite for blood-urine barrier formation and enables normal sensory function of the urinary bladder. In this study, urothelial differentiation of normal human urothelium and of low and high grade papillary urothelial carcinomas was correlated with the expression and localization of purinergic receptors (P2X3, and P2X5) and transient receptor potential vanilloid channels (TRPV1, and TRPV4). Western blotting and immunofluorescence of uroplakins together with scanning electron microscopy of urothelial apical surface demonstrated terminal differentiation of normal urothelium, partial differentiation of low grade carcinoma, and poor differentiation of high grade carcinoma. P2X3 was expressed in normal urothelium as well as in low grade carcinoma and in both cases immunolabeling was stronger in the superficial cells. P2X3 expression decreased in high grade carcinoma. P2X5 expression was detected in normal urothelium and in high grade carcinoma, while in low grade carcinoma its expression was diminished. The expression of TRPV1 decreased in low grade and even more in high grade carcinoma when compared with normal urothelium, while TRPV4 expression was unchanged in all samples. Our results suggest that sensory proteins P2X3 and TRPV1 are in correlation with urothelial differentiation, while P2X5 and TRPV4 have unique expression patterns.
doi_str_mv 10.1155/2014/805236
format article
fullrecord <record><control><sourceid>gale_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4020497</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><galeid>A427024518</galeid><sourcerecordid>A427024518</sourcerecordid><originalsourceid>FETCH-LOGICAL-c527t-fe9959250a6e4b7fe3bd00ba1553f077eb61fd6e95b60da2d34fe6fbafc9ab173</originalsourceid><addsrcrecordid>eNqN0stu1DAUBuAIgWhVumINssQGwQz1PfGmUhkuRapgBC1iZznJcesqsQc7oeJleFacph0uG8jCseRPv32OTlE8JPgFIUIcUEz4QYUFZfJOsUsZ4UtJOLm73TO2U-yndInzVxGJlbxf7FBeyUrwcrf4sQoxQmcGFzyqYbgC8OgshuECOmc69MpZCxH84GZifIs-gU8hfkfrzMD5hNb0C1tMq1ig04_rz2Rx7aYtR86j9yH2Oes2duyvj9dm47rO5KCViY3zoTcoWHQ89sajl51pW4gPinvWdAn2b_57xdmb16er4-XJh7fvVkcny0bQclhaUEooKrCRwOvSAqtbjGuTO8QsLkuoJbGtBCVqiVtDW8YtSFsb2yhTk5LtFYdz7mase2ibXHA0nd5E1-cH6mCc_vPEuwt9Hr5pjinmagp4ehMQw9cR0qB7lxrI9XkIY9JESFlRxen_UIYZJUSRTJ_8RS_DGH3uRFa8VJSXFf-lzk0H2nkb8hObKVQf5Qsx5YJUWT2fVRNDShHstjqC9TRLepolPc9S1o9_b8jW3k5OBs9mcOF8a67cP9IezRgyAWu2mCvFBWM_Ac4b2aI</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1547924784</pqid></control><display><type>article</type><title>Correlation between Urothelial Differentiation and Sensory Proteins P2X3, P2X5, TRPV1, and TRPV4 in Normal Urothelium and Papillary Carcinoma of Human Bladder</title><source>Wiley Online Library Open Access</source><source>Publicly Available Content Database</source><creator>Sterle, Igor ; Zupančič, Daša ; Romih, Rok</creator><contributor>Winder, Michael</contributor><creatorcontrib>Sterle, Igor ; Zupančič, Daša ; Romih, Rok ; Winder, Michael</creatorcontrib><description>Terminal differentiation of urothelium is a prerequisite for blood-urine barrier formation and enables normal sensory function of the urinary bladder. In this study, urothelial differentiation of normal human urothelium and of low and high grade papillary urothelial carcinomas was correlated with the expression and localization of purinergic receptors (P2X3, and P2X5) and transient receptor potential vanilloid channels (TRPV1, and TRPV4). Western blotting and immunofluorescence of uroplakins together with scanning electron microscopy of urothelial apical surface demonstrated terminal differentiation of normal urothelium, partial differentiation of low grade carcinoma, and poor differentiation of high grade carcinoma. P2X3 was expressed in normal urothelium as well as in low grade carcinoma and in both cases immunolabeling was stronger in the superficial cells. P2X3 expression decreased in high grade carcinoma. P2X5 expression was detected in normal urothelium and in high grade carcinoma, while in low grade carcinoma its expression was diminished. The expression of TRPV1 decreased in low grade and even more in high grade carcinoma when compared with normal urothelium, while TRPV4 expression was unchanged in all samples. Our results suggest that sensory proteins P2X3 and TRPV1 are in correlation with urothelial differentiation, while P2X5 and TRPV4 have unique expression patterns.</description><identifier>ISSN: 2314-6133</identifier><identifier>EISSN: 2314-6141</identifier><identifier>DOI: 10.1155/2014/805236</identifier><identifier>PMID: 24868547</identifier><language>eng</language><publisher>Cairo, Egypt: Hindawi Puplishing Corporation</publisher><subject>Aged ; Aged, 80 and over ; Biomedical research ; Biopsy ; Bladder cancer ; Carcinoma, Papillary - metabolism ; Cell Differentiation ; Excretory system ; Gene Expression Profiling ; Gene Expression Regulation, Neoplastic ; Humans ; Hypotheses ; Microscopy, Electron, Scanning ; Microscopy, Fluorescence ; Middle Aged ; Pathogenesis ; Patients ; Permeability ; Prognosis ; Proteins ; Receptors, Purinergic P2X3 - metabolism ; Receptors, Purinergic P2X5 - metabolism ; Rodents ; Studies ; TRPV Cation Channels - metabolism ; Tumors ; Urinary Bladder Neoplasms - metabolism ; Urothelium ; Urothelium - cytology</subject><ispartof>BioMed research international, 2014-01, Vol.2014 (2014), p.1-9</ispartof><rights>Copyright © 2014 Igor Sterle et al.</rights><rights>COPYRIGHT 2014 John Wiley &amp; Sons, Inc.</rights><rights>Copyright © 2014 Igor Sterle et al. Igor Sterle et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.</rights><rights>Copyright © 2014 Igor Sterle et al. 2014</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c527t-fe9959250a6e4b7fe3bd00ba1553f077eb61fd6e95b60da2d34fe6fbafc9ab173</citedby><cites>FETCH-LOGICAL-c527t-fe9959250a6e4b7fe3bd00ba1553f077eb61fd6e95b60da2d34fe6fbafc9ab173</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.proquest.com/docview/1547924784/fulltextPDF?pq-origsite=primo$$EPDF$$P50$$Gproquest$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.proquest.com/docview/1547924784?pq-origsite=primo$$EHTML$$P50$$Gproquest$$Hfree_for_read</linktohtml><link.rule.ids>230,314,780,784,885,25753,27924,27925,37012,37013,44590,74998</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/24868547$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><contributor>Winder, Michael</contributor><creatorcontrib>Sterle, Igor</creatorcontrib><creatorcontrib>Zupančič, Daša</creatorcontrib><creatorcontrib>Romih, Rok</creatorcontrib><title>Correlation between Urothelial Differentiation and Sensory Proteins P2X3, P2X5, TRPV1, and TRPV4 in Normal Urothelium and Papillary Carcinoma of Human Bladder</title><title>BioMed research international</title><addtitle>Biomed Res Int</addtitle><description>Terminal differentiation of urothelium is a prerequisite for blood-urine barrier formation and enables normal sensory function of the urinary bladder. In this study, urothelial differentiation of normal human urothelium and of low and high grade papillary urothelial carcinomas was correlated with the expression and localization of purinergic receptors (P2X3, and P2X5) and transient receptor potential vanilloid channels (TRPV1, and TRPV4). Western blotting and immunofluorescence of uroplakins together with scanning electron microscopy of urothelial apical surface demonstrated terminal differentiation of normal urothelium, partial differentiation of low grade carcinoma, and poor differentiation of high grade carcinoma. P2X3 was expressed in normal urothelium as well as in low grade carcinoma and in both cases immunolabeling was stronger in the superficial cells. P2X3 expression decreased in high grade carcinoma. P2X5 expression was detected in normal urothelium and in high grade carcinoma, while in low grade carcinoma its expression was diminished. The expression of TRPV1 decreased in low grade and even more in high grade carcinoma when compared with normal urothelium, while TRPV4 expression was unchanged in all samples. Our results suggest that sensory proteins P2X3 and TRPV1 are in correlation with urothelial differentiation, while P2X5 and TRPV4 have unique expression patterns.</description><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Biomedical research</subject><subject>Biopsy</subject><subject>Bladder cancer</subject><subject>Carcinoma, Papillary - metabolism</subject><subject>Cell Differentiation</subject><subject>Excretory system</subject><subject>Gene Expression Profiling</subject><subject>Gene Expression Regulation, Neoplastic</subject><subject>Humans</subject><subject>Hypotheses</subject><subject>Microscopy, Electron, Scanning</subject><subject>Microscopy, Fluorescence</subject><subject>Middle Aged</subject><subject>Pathogenesis</subject><subject>Patients</subject><subject>Permeability</subject><subject>Prognosis</subject><subject>Proteins</subject><subject>Receptors, Purinergic P2X3 - metabolism</subject><subject>Receptors, Purinergic P2X5 - metabolism</subject><subject>Rodents</subject><subject>Studies</subject><subject>TRPV Cation Channels - metabolism</subject><subject>Tumors</subject><subject>Urinary Bladder Neoplasms - metabolism</subject><subject>Urothelium</subject><subject>Urothelium - cytology</subject><issn>2314-6133</issn><issn>2314-6141</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2014</creationdate><recordtype>article</recordtype><sourceid>PIMPY</sourceid><recordid>eNqN0stu1DAUBuAIgWhVumINssQGwQz1PfGmUhkuRapgBC1iZznJcesqsQc7oeJleFacph0uG8jCseRPv32OTlE8JPgFIUIcUEz4QYUFZfJOsUsZ4UtJOLm73TO2U-yndInzVxGJlbxf7FBeyUrwcrf4sQoxQmcGFzyqYbgC8OgshuECOmc69MpZCxH84GZifIs-gU8hfkfrzMD5hNb0C1tMq1ig04_rz2Rx7aYtR86j9yH2Oes2duyvj9dm47rO5KCViY3zoTcoWHQ89sajl51pW4gPinvWdAn2b_57xdmb16er4-XJh7fvVkcny0bQclhaUEooKrCRwOvSAqtbjGuTO8QsLkuoJbGtBCVqiVtDW8YtSFsb2yhTk5LtFYdz7mase2ibXHA0nd5E1-cH6mCc_vPEuwt9Hr5pjinmagp4ehMQw9cR0qB7lxrI9XkIY9JESFlRxen_UIYZJUSRTJ_8RS_DGH3uRFa8VJSXFf-lzk0H2nkb8hObKVQf5Qsx5YJUWT2fVRNDShHstjqC9TRLepolPc9S1o9_b8jW3k5OBs9mcOF8a67cP9IezRgyAWu2mCvFBWM_Ac4b2aI</recordid><startdate>20140101</startdate><enddate>20140101</enddate><creator>Sterle, Igor</creator><creator>Zupančič, Daša</creator><creator>Romih, Rok</creator><general>Hindawi Puplishing Corporation</general><general>Hindawi Publishing Corporation</general><general>John Wiley &amp; Sons, Inc</general><general>Hindawi Limited</general><scope>ADJCN</scope><scope>AHFXO</scope><scope>RHU</scope><scope>RHW</scope><scope>RHX</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QL</scope><scope>7QO</scope><scope>7T7</scope><scope>7TK</scope><scope>7U7</scope><scope>7U9</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8FD</scope><scope>8FE</scope><scope>8FG</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>ARAPS</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BGLVJ</scope><scope>BHPHI</scope><scope>C1K</scope><scope>CCPQU</scope><scope>CWDGH</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M7N</scope><scope>M7P</scope><scope>P5Z</scope><scope>P62</scope><scope>P64</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20140101</creationdate><title>Correlation between Urothelial Differentiation and Sensory Proteins P2X3, P2X5, TRPV1, and TRPV4 in Normal Urothelium and Papillary Carcinoma of Human Bladder</title><author>Sterle, Igor ; Zupančič, Daša ; Romih, Rok</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c527t-fe9959250a6e4b7fe3bd00ba1553f077eb61fd6e95b60da2d34fe6fbafc9ab173</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2014</creationdate><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Biomedical research</topic><topic>Biopsy</topic><topic>Bladder cancer</topic><topic>Carcinoma, Papillary - metabolism</topic><topic>Cell Differentiation</topic><topic>Excretory system</topic><topic>Gene Expression Profiling</topic><topic>Gene Expression Regulation, Neoplastic</topic><topic>Humans</topic><topic>Hypotheses</topic><topic>Microscopy, Electron, Scanning</topic><topic>Microscopy, Fluorescence</topic><topic>Middle Aged</topic><topic>Pathogenesis</topic><topic>Patients</topic><topic>Permeability</topic><topic>Prognosis</topic><topic>Proteins</topic><topic>Receptors, Purinergic P2X3 - metabolism</topic><topic>Receptors, Purinergic P2X5 - metabolism</topic><topic>Rodents</topic><topic>Studies</topic><topic>TRPV Cation Channels - metabolism</topic><topic>Tumors</topic><topic>Urinary Bladder Neoplasms - metabolism</topic><topic>Urothelium</topic><topic>Urothelium - cytology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Sterle, Igor</creatorcontrib><creatorcontrib>Zupančič, Daša</creatorcontrib><creatorcontrib>Romih, Rok</creatorcontrib><collection>الدوريات العلمية والإحصائية - e-Marefa Academic and Statistical Periodicals</collection><collection>معرفة - المحتوى العربي الأكاديمي المتكامل - e-Marefa Academic Complete</collection><collection>Hindawi Publishing Complete</collection><collection>Hindawi Publishing Subscription Journals</collection><collection>Hindawi Publishing Open Access Journals</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Biotechnology Research Abstracts</collection><collection>Industrial and Applied Microbiology Abstracts (Microbiology A)</collection><collection>Neurosciences Abstracts</collection><collection>Toxicology Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>ProQuest Health &amp; Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Technology Research Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Technology Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni)</collection><collection>ProQuest Central</collection><collection>Advanced Technologies &amp; Aerospace Collection</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Technology Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ProQuest One Community College</collection><collection>ProQuest Middle East &amp; Africa Database</collection><collection>ProQuest Central</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>SciTech Premium Collection (Proquest) (PQ_SDU_P3)</collection><collection>ProQuest Health &amp; Medical Complete (Alumni)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health &amp; Medical Collection (Alumni Edition)</collection><collection>PML(ProQuest Medical Library)</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>ProQuest Biological Science Journals</collection><collection>Advanced Technologies &amp; Aerospace Database</collection><collection>ProQuest Advanced Technologies &amp; Aerospace Collection</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Publicly Available Content Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>BioMed research international</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Sterle, Igor</au><au>Zupančič, Daša</au><au>Romih, Rok</au><au>Winder, Michael</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Correlation between Urothelial Differentiation and Sensory Proteins P2X3, P2X5, TRPV1, and TRPV4 in Normal Urothelium and Papillary Carcinoma of Human Bladder</atitle><jtitle>BioMed research international</jtitle><addtitle>Biomed Res Int</addtitle><date>2014-01-01</date><risdate>2014</risdate><volume>2014</volume><issue>2014</issue><spage>1</spage><epage>9</epage><pages>1-9</pages><issn>2314-6133</issn><eissn>2314-6141</eissn><abstract>Terminal differentiation of urothelium is a prerequisite for blood-urine barrier formation and enables normal sensory function of the urinary bladder. In this study, urothelial differentiation of normal human urothelium and of low and high grade papillary urothelial carcinomas was correlated with the expression and localization of purinergic receptors (P2X3, and P2X5) and transient receptor potential vanilloid channels (TRPV1, and TRPV4). Western blotting and immunofluorescence of uroplakins together with scanning electron microscopy of urothelial apical surface demonstrated terminal differentiation of normal urothelium, partial differentiation of low grade carcinoma, and poor differentiation of high grade carcinoma. P2X3 was expressed in normal urothelium as well as in low grade carcinoma and in both cases immunolabeling was stronger in the superficial cells. P2X3 expression decreased in high grade carcinoma. P2X5 expression was detected in normal urothelium and in high grade carcinoma, while in low grade carcinoma its expression was diminished. The expression of TRPV1 decreased in low grade and even more in high grade carcinoma when compared with normal urothelium, while TRPV4 expression was unchanged in all samples. Our results suggest that sensory proteins P2X3 and TRPV1 are in correlation with urothelial differentiation, while P2X5 and TRPV4 have unique expression patterns.</abstract><cop>Cairo, Egypt</cop><pub>Hindawi Puplishing Corporation</pub><pmid>24868547</pmid><doi>10.1155/2014/805236</doi><tpages>9</tpages><oa>free_for_read</oa></addata></record>
fulltext fulltext
identifier ISSN: 2314-6133
ispartof BioMed research international, 2014-01, Vol.2014 (2014), p.1-9
issn 2314-6133
2314-6141
language eng
recordid cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4020497
source Wiley Online Library Open Access; Publicly Available Content Database
subjects Aged
Aged, 80 and over
Biomedical research
Biopsy
Bladder cancer
Carcinoma, Papillary - metabolism
Cell Differentiation
Excretory system
Gene Expression Profiling
Gene Expression Regulation, Neoplastic
Humans
Hypotheses
Microscopy, Electron, Scanning
Microscopy, Fluorescence
Middle Aged
Pathogenesis
Patients
Permeability
Prognosis
Proteins
Receptors, Purinergic P2X3 - metabolism
Receptors, Purinergic P2X5 - metabolism
Rodents
Studies
TRPV Cation Channels - metabolism
Tumors
Urinary Bladder Neoplasms - metabolism
Urothelium
Urothelium - cytology
title Correlation between Urothelial Differentiation and Sensory Proteins P2X3, P2X5, TRPV1, and TRPV4 in Normal Urothelium and Papillary Carcinoma of Human Bladder
url http://sfxeu10.hosted.exlibrisgroup.com/loughborough?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-07T15%3A54%3A36IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-gale_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Correlation%20between%20Urothelial%20Differentiation%20and%20Sensory%20Proteins%20P2X3,%20P2X5,%20TRPV1,%20and%20TRPV4%20in%20Normal%20Urothelium%20and%20Papillary%20Carcinoma%20of%20Human%20Bladder&rft.jtitle=BioMed%20research%20international&rft.au=Sterle,%20Igor&rft.date=2014-01-01&rft.volume=2014&rft.issue=2014&rft.spage=1&rft.epage=9&rft.pages=1-9&rft.issn=2314-6133&rft.eissn=2314-6141&rft_id=info:doi/10.1155/2014/805236&rft_dat=%3Cgale_pubme%3EA427024518%3C/gale_pubme%3E%3Cgrp_id%3Ecdi_FETCH-LOGICAL-c527t-fe9959250a6e4b7fe3bd00ba1553f077eb61fd6e95b60da2d34fe6fbafc9ab173%3C/grp_id%3E%3Coa%3E%3C/oa%3E%3Curl%3E%3C/url%3E&rft_id=info:oai/&rft_pqid=1547924784&rft_id=info:pmid/24868547&rft_galeid=A427024518&rfr_iscdi=true