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Correlation between Urothelial Differentiation and Sensory Proteins P2X3, P2X5, TRPV1, and TRPV4 in Normal Urothelium and Papillary Carcinoma of Human Bladder
Terminal differentiation of urothelium is a prerequisite for blood-urine barrier formation and enables normal sensory function of the urinary bladder. In this study, urothelial differentiation of normal human urothelium and of low and high grade papillary urothelial carcinomas was correlated with th...
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Published in: | BioMed research international 2014-01, Vol.2014 (2014), p.1-9 |
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description | Terminal differentiation of urothelium is a prerequisite for blood-urine barrier formation and enables normal sensory function of the urinary bladder. In this study, urothelial differentiation of normal human urothelium and of low and high grade papillary urothelial carcinomas was correlated with the expression and localization of purinergic receptors (P2X3, and P2X5) and transient receptor potential vanilloid channels (TRPV1, and TRPV4). Western blotting and immunofluorescence of uroplakins together with scanning electron microscopy of urothelial apical surface demonstrated terminal differentiation of normal urothelium, partial differentiation of low grade carcinoma, and poor differentiation of high grade carcinoma. P2X3 was expressed in normal urothelium as well as in low grade carcinoma and in both cases immunolabeling was stronger in the superficial cells. P2X3 expression decreased in high grade carcinoma. P2X5 expression was detected in normal urothelium and in high grade carcinoma, while in low grade carcinoma its expression was diminished. The expression of TRPV1 decreased in low grade and even more in high grade carcinoma when compared with normal urothelium, while TRPV4 expression was unchanged in all samples. Our results suggest that sensory proteins P2X3 and TRPV1 are in correlation with urothelial differentiation, while P2X5 and TRPV4 have unique expression patterns. |
doi_str_mv | 10.1155/2014/805236 |
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In this study, urothelial differentiation of normal human urothelium and of low and high grade papillary urothelial carcinomas was correlated with the expression and localization of purinergic receptors (P2X3, and P2X5) and transient receptor potential vanilloid channels (TRPV1, and TRPV4). Western blotting and immunofluorescence of uroplakins together with scanning electron microscopy of urothelial apical surface demonstrated terminal differentiation of normal urothelium, partial differentiation of low grade carcinoma, and poor differentiation of high grade carcinoma. P2X3 was expressed in normal urothelium as well as in low grade carcinoma and in both cases immunolabeling was stronger in the superficial cells. P2X3 expression decreased in high grade carcinoma. P2X5 expression was detected in normal urothelium and in high grade carcinoma, while in low grade carcinoma its expression was diminished. The expression of TRPV1 decreased in low grade and even more in high grade carcinoma when compared with normal urothelium, while TRPV4 expression was unchanged in all samples. Our results suggest that sensory proteins P2X3 and TRPV1 are in correlation with urothelial differentiation, while P2X5 and TRPV4 have unique expression patterns.</description><identifier>ISSN: 2314-6133</identifier><identifier>EISSN: 2314-6141</identifier><identifier>DOI: 10.1155/2014/805236</identifier><identifier>PMID: 24868547</identifier><language>eng</language><publisher>Cairo, Egypt: Hindawi Puplishing Corporation</publisher><subject>Aged ; Aged, 80 and over ; Biomedical research ; Biopsy ; Bladder cancer ; Carcinoma, Papillary - metabolism ; Cell Differentiation ; Excretory system ; Gene Expression Profiling ; Gene Expression Regulation, Neoplastic ; Humans ; Hypotheses ; Microscopy, Electron, Scanning ; Microscopy, Fluorescence ; Middle Aged ; Pathogenesis ; Patients ; Permeability ; Prognosis ; Proteins ; Receptors, Purinergic P2X3 - metabolism ; Receptors, Purinergic P2X5 - metabolism ; Rodents ; Studies ; TRPV Cation Channels - metabolism ; Tumors ; Urinary Bladder Neoplasms - metabolism ; Urothelium ; Urothelium - cytology</subject><ispartof>BioMed research international, 2014-01, Vol.2014 (2014), p.1-9</ispartof><rights>Copyright © 2014 Igor Sterle et al.</rights><rights>COPYRIGHT 2014 John Wiley & Sons, Inc.</rights><rights>Copyright © 2014 Igor Sterle et al. Igor Sterle et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.</rights><rights>Copyright © 2014 Igor Sterle et al. 2014</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c527t-fe9959250a6e4b7fe3bd00ba1553f077eb61fd6e95b60da2d34fe6fbafc9ab173</citedby><cites>FETCH-LOGICAL-c527t-fe9959250a6e4b7fe3bd00ba1553f077eb61fd6e95b60da2d34fe6fbafc9ab173</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.proquest.com/docview/1547924784/fulltextPDF?pq-origsite=primo$$EPDF$$P50$$Gproquest$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.proquest.com/docview/1547924784?pq-origsite=primo$$EHTML$$P50$$Gproquest$$Hfree_for_read</linktohtml><link.rule.ids>230,314,780,784,885,25753,27924,27925,37012,37013,44590,74998</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/24868547$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><contributor>Winder, Michael</contributor><creatorcontrib>Sterle, Igor</creatorcontrib><creatorcontrib>Zupančič, Daša</creatorcontrib><creatorcontrib>Romih, Rok</creatorcontrib><title>Correlation between Urothelial Differentiation and Sensory Proteins P2X3, P2X5, TRPV1, and TRPV4 in Normal Urothelium and Papillary Carcinoma of Human Bladder</title><title>BioMed research international</title><addtitle>Biomed Res Int</addtitle><description>Terminal differentiation of urothelium is a prerequisite for blood-urine barrier formation and enables normal sensory function of the urinary bladder. In this study, urothelial differentiation of normal human urothelium and of low and high grade papillary urothelial carcinomas was correlated with the expression and localization of purinergic receptors (P2X3, and P2X5) and transient receptor potential vanilloid channels (TRPV1, and TRPV4). Western blotting and immunofluorescence of uroplakins together with scanning electron microscopy of urothelial apical surface demonstrated terminal differentiation of normal urothelium, partial differentiation of low grade carcinoma, and poor differentiation of high grade carcinoma. P2X3 was expressed in normal urothelium as well as in low grade carcinoma and in both cases immunolabeling was stronger in the superficial cells. P2X3 expression decreased in high grade carcinoma. P2X5 expression was detected in normal urothelium and in high grade carcinoma, while in low grade carcinoma its expression was diminished. The expression of TRPV1 decreased in low grade and even more in high grade carcinoma when compared with normal urothelium, while TRPV4 expression was unchanged in all samples. Our results suggest that sensory proteins P2X3 and TRPV1 are in correlation with urothelial differentiation, while P2X5 and TRPV4 have unique expression patterns.</description><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Biomedical research</subject><subject>Biopsy</subject><subject>Bladder cancer</subject><subject>Carcinoma, Papillary - metabolism</subject><subject>Cell Differentiation</subject><subject>Excretory system</subject><subject>Gene Expression Profiling</subject><subject>Gene Expression Regulation, Neoplastic</subject><subject>Humans</subject><subject>Hypotheses</subject><subject>Microscopy, Electron, Scanning</subject><subject>Microscopy, Fluorescence</subject><subject>Middle Aged</subject><subject>Pathogenesis</subject><subject>Patients</subject><subject>Permeability</subject><subject>Prognosis</subject><subject>Proteins</subject><subject>Receptors, Purinergic P2X3 - metabolism</subject><subject>Receptors, Purinergic P2X5 - metabolism</subject><subject>Rodents</subject><subject>Studies</subject><subject>TRPV Cation Channels - metabolism</subject><subject>Tumors</subject><subject>Urinary Bladder Neoplasms - metabolism</subject><subject>Urothelium</subject><subject>Urothelium - cytology</subject><issn>2314-6133</issn><issn>2314-6141</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2014</creationdate><recordtype>article</recordtype><sourceid>PIMPY</sourceid><recordid>eNqN0stu1DAUBuAIgWhVumINssQGwQz1PfGmUhkuRapgBC1iZznJcesqsQc7oeJleFacph0uG8jCseRPv32OTlE8JPgFIUIcUEz4QYUFZfJOsUsZ4UtJOLm73TO2U-yndInzVxGJlbxf7FBeyUrwcrf4sQoxQmcGFzyqYbgC8OgshuECOmc69MpZCxH84GZifIs-gU8hfkfrzMD5hNb0C1tMq1ig04_rz2Rx7aYtR86j9yH2Oes2duyvj9dm47rO5KCViY3zoTcoWHQ89sajl51pW4gPinvWdAn2b_57xdmb16er4-XJh7fvVkcny0bQclhaUEooKrCRwOvSAqtbjGuTO8QsLkuoJbGtBCVqiVtDW8YtSFsb2yhTk5LtFYdz7mase2ibXHA0nd5E1-cH6mCc_vPEuwt9Hr5pjinmagp4ehMQw9cR0qB7lxrI9XkIY9JESFlRxen_UIYZJUSRTJ_8RS_DGH3uRFa8VJSXFf-lzk0H2nkb8hObKVQf5Qsx5YJUWT2fVRNDShHstjqC9TRLepolPc9S1o9_b8jW3k5OBs9mcOF8a67cP9IezRgyAWu2mCvFBWM_Ac4b2aI</recordid><startdate>20140101</startdate><enddate>20140101</enddate><creator>Sterle, Igor</creator><creator>Zupančič, Daša</creator><creator>Romih, Rok</creator><general>Hindawi Puplishing Corporation</general><general>Hindawi Publishing Corporation</general><general>John Wiley & Sons, Inc</general><general>Hindawi Limited</general><scope>ADJCN</scope><scope>AHFXO</scope><scope>RHU</scope><scope>RHW</scope><scope>RHX</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QL</scope><scope>7QO</scope><scope>7T7</scope><scope>7TK</scope><scope>7U7</scope><scope>7U9</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8FD</scope><scope>8FE</scope><scope>8FG</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>ARAPS</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BGLVJ</scope><scope>BHPHI</scope><scope>C1K</scope><scope>CCPQU</scope><scope>CWDGH</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M7N</scope><scope>M7P</scope><scope>P5Z</scope><scope>P62</scope><scope>P64</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20140101</creationdate><title>Correlation between Urothelial Differentiation and Sensory Proteins P2X3, P2X5, TRPV1, and TRPV4 in Normal Urothelium and Papillary Carcinoma of Human Bladder</title><author>Sterle, Igor ; Zupančič, Daša ; Romih, Rok</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c527t-fe9959250a6e4b7fe3bd00ba1553f077eb61fd6e95b60da2d34fe6fbafc9ab173</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2014</creationdate><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Biomedical research</topic><topic>Biopsy</topic><topic>Bladder cancer</topic><topic>Carcinoma, Papillary - metabolism</topic><topic>Cell Differentiation</topic><topic>Excretory system</topic><topic>Gene Expression Profiling</topic><topic>Gene Expression Regulation, Neoplastic</topic><topic>Humans</topic><topic>Hypotheses</topic><topic>Microscopy, Electron, Scanning</topic><topic>Microscopy, Fluorescence</topic><topic>Middle Aged</topic><topic>Pathogenesis</topic><topic>Patients</topic><topic>Permeability</topic><topic>Prognosis</topic><topic>Proteins</topic><topic>Receptors, Purinergic P2X3 - metabolism</topic><topic>Receptors, Purinergic P2X5 - metabolism</topic><topic>Rodents</topic><topic>Studies</topic><topic>TRPV Cation Channels - metabolism</topic><topic>Tumors</topic><topic>Urinary Bladder Neoplasms - metabolism</topic><topic>Urothelium</topic><topic>Urothelium - cytology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Sterle, Igor</creatorcontrib><creatorcontrib>Zupančič, Daša</creatorcontrib><creatorcontrib>Romih, Rok</creatorcontrib><collection>الدوريات العلمية والإحصائية - 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Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>BioMed research international</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Sterle, Igor</au><au>Zupančič, Daša</au><au>Romih, Rok</au><au>Winder, Michael</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Correlation between Urothelial Differentiation and Sensory Proteins P2X3, P2X5, TRPV1, and TRPV4 in Normal Urothelium and Papillary Carcinoma of Human Bladder</atitle><jtitle>BioMed research international</jtitle><addtitle>Biomed Res Int</addtitle><date>2014-01-01</date><risdate>2014</risdate><volume>2014</volume><issue>2014</issue><spage>1</spage><epage>9</epage><pages>1-9</pages><issn>2314-6133</issn><eissn>2314-6141</eissn><abstract>Terminal differentiation of urothelium is a prerequisite for blood-urine barrier formation and enables normal sensory function of the urinary bladder. In this study, urothelial differentiation of normal human urothelium and of low and high grade papillary urothelial carcinomas was correlated with the expression and localization of purinergic receptors (P2X3, and P2X5) and transient receptor potential vanilloid channels (TRPV1, and TRPV4). Western blotting and immunofluorescence of uroplakins together with scanning electron microscopy of urothelial apical surface demonstrated terminal differentiation of normal urothelium, partial differentiation of low grade carcinoma, and poor differentiation of high grade carcinoma. P2X3 was expressed in normal urothelium as well as in low grade carcinoma and in both cases immunolabeling was stronger in the superficial cells. P2X3 expression decreased in high grade carcinoma. P2X5 expression was detected in normal urothelium and in high grade carcinoma, while in low grade carcinoma its expression was diminished. The expression of TRPV1 decreased in low grade and even more in high grade carcinoma when compared with normal urothelium, while TRPV4 expression was unchanged in all samples. Our results suggest that sensory proteins P2X3 and TRPV1 are in correlation with urothelial differentiation, while P2X5 and TRPV4 have unique expression patterns.</abstract><cop>Cairo, Egypt</cop><pub>Hindawi Puplishing Corporation</pub><pmid>24868547</pmid><doi>10.1155/2014/805236</doi><tpages>9</tpages><oa>free_for_read</oa></addata></record> |
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subjects | Aged Aged, 80 and over Biomedical research Biopsy Bladder cancer Carcinoma, Papillary - metabolism Cell Differentiation Excretory system Gene Expression Profiling Gene Expression Regulation, Neoplastic Humans Hypotheses Microscopy, Electron, Scanning Microscopy, Fluorescence Middle Aged Pathogenesis Patients Permeability Prognosis Proteins Receptors, Purinergic P2X3 - metabolism Receptors, Purinergic P2X5 - metabolism Rodents Studies TRPV Cation Channels - metabolism Tumors Urinary Bladder Neoplasms - metabolism Urothelium Urothelium - cytology |
title | Correlation between Urothelial Differentiation and Sensory Proteins P2X3, P2X5, TRPV1, and TRPV4 in Normal Urothelium and Papillary Carcinoma of Human Bladder |
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