Plasma protein biomarkers of the geriatric syndrome of frailty

Frailty is a geriatric syndrome associated with physical decline with aging. Using a proteomics-based screening method to screen plasma for potential biomarkers, we previously found inflammatory glycoproteins to be increased with frailty. The purpose of this study was to confirm if plasma levels of...

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Bibliographic Details
Published in:The journals of gerontology. Series A, Biological sciences and medical sciences Biological sciences and medical sciences, 2014-02, Vol.69 (2), p.182-186
Main Authors: Darvin, Kayla, Randolph, Amanda, Ovalles, Symphony, Halade, Dipti, Breeding, Leah, Richardson, Arlan, Espinoza, Sara E
Format: Article
Language:English
Subjects:
Aged
Aged, 80 and over
Aging
Biomarkers
Biomarkers - blood
Brief Report
Case-Control Studies
Cohort Studies
Enzyme-Linked Immunosorbent Assay
Fibrinogen - metabolism
Frail Elderly
Frailty
Gait - physiology
Geriatric Assessment
Geriatrics
Glycoproteins
Hand Strength - physiology
Haptoglobins - metabolism
Humans
Interleukin-6 - blood
Motor Activity - physiology
Proteomics
Syndrome
Transferrin - metabolism
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Summary:Frailty is a geriatric syndrome associated with physical decline with aging. Using a proteomics-based screening method to screen plasma for potential biomarkers, we previously found inflammatory glycoproteins to be increased with frailty. The purpose of this study was to confirm if plasma levels of these glycoproteins, as well as of interleukin-6, are increased with frailty in a larger sample (n = 65) of community-dwelling older adults. Plasma levels of transferrin, fibrinogen, haptoglobin, and interleukin-6 were determined with enzyme-linked immunosorbent assay. Differences in protein concentrations by frailty status were determined using analysis of variance. Higher levels of transferrin (p < .001), fibrinogen (p < .0001), and interleukin-6 (p = .0035) were associated with frailty status (nonfrail, prefrail, or frail) and frailty score (0-5) in this sample even after adjustment for age and sex. Haptoglobin did not differ by frailty status (p = .05). Our findings largely confirmed the findings of our nontargeted approach that inflammatory glycoproteins are increased with frailty. Future studies should include larger examinations of these associations and consider the potential usefulness of these glycoproteins as biomarkers for frailty.
ISSN:1079-5006
1758-535X
DOI:10.1093/gerona/glt183