Effects of garcinia cambogia (Hydroxycitric Acid) on visceral fat accumulation: a double-blind, randomized, placebo-controlled trial

(-)-Hydroxycitric acid (HCA) is an active ingredient extracted from the rind of the Indian fruit Garcinia cambogia. It inhibits adenosine triphosphate citrate lyase and has been used in the treatment of obesity. The primary end point of this study was the effects of 12 weeks of G cambogia extract ad...

Full description

Saved in:
Bibliographic Details
Published in:Current therapeutic research 2003-09, Vol.64 (8), p.551-567
Main Authors: Hayamizu, Kohsuke, Ishii, Yuri, Kaneko, Izuru, Shen, Manzhen, Okuhara, Yasuhide, Shigematsu, Norihiro, Tomi, Hironori, Furuse, Mitsuhiro, Yoshino, Gen, Shimasaki, Hiroyuki
Format: Article
Language:English
Subjects:
Biological and medical sciences
computed tomography scan
Garcinia cambogia
General pharmacology
hydroxycitric acid
Medical sciences
Pharmacognosy. Homeopathy. Health food
Pharmacology. Drug treatments
visceral fat accumulation
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:(-)-Hydroxycitric acid (HCA) is an active ingredient extracted from the rind of the Indian fruit Garcinia cambogia. It inhibits adenosine triphosphate citrate lyase and has been used in the treatment of obesity. The primary end point of this study was the effects of 12 weeks of G cambogia extract administration on visceral fat accumulation. The secondary end points were body indices (including height, body weight, body mass index [BMI], waist and hip circumference, and waist–hip ratio) and laboratory values (including total cholesterol, triacylglycerol, and free fatty acid). This study was performed according to a double-blind, randomized, placebo-controlled, parallel-group design. Subjects aged 20 to 65 years with a visceral fat area >90 cm2 were enrolled. Subjects were randomly assigned to receive treatment for 12 weeks with G cambogia (containing 1000 mg of HCA per day) or placebo. At the end of the treatment period, both groups were administered placebo for 4 weeks to assess any rebound effect. Each subject underwent a computed tomography scan at the umbilical level at −2, 0, 12, and 16 weeks. Forty-four subjects were randomized at baseline, and 39 completed the study (G cambogia group, n=18; placebo group, n=21). At 16 weeks, the G cambogia group had significantly reduced visceral, subcutaneous, and total fat areas compared with the placebo group (all indices P
ISSN:0011-393X
1879-0313
DOI:10.1016/j.curtheres.2003.08.006