Genome scan for cognitive trait loci of dyslexia: Rapid naming and rapid switching of letters, numbers, and colors

Dyslexia, or specific reading disability, is a common developmental disorder that affects 5–12% of school‐aged children. Dyslexia and its component phenotypes, assessed categorically or quantitatively, have complex genetic bases. The ability to rapidly name letters, numbers, and colors from rows pre...

Full description

Saved in:
Bibliographic Details
Published in:American journal of medical genetics. Part B, Neuropsychiatric genetics Neuropsychiatric genetics, 2014-06, Vol.165B (4), p.345-356
Main Authors: Rubenstein, Kevin B., Raskind, Wendy H., Berninger, Virginia W., Matsushita, Mark M., Wijsman, Ellen M.
Format: Article
Language:English
Subjects:
Adolescent
Bayes Theorem
Child
Chromosome Segregation - genetics
Cognition
Color
complex trait
Confidence Intervals
Dyslexia - genetics
general pedigrees
Genetic Linkage
Genetics
Genome-Wide Association Study
Humans
Language
learning disabilities
Mathematics
MCMC
Quantitative Trait Loci - genetics
rapid automatized naming
Reading
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Dyslexia, or specific reading disability, is a common developmental disorder that affects 5–12% of school‐aged children. Dyslexia and its component phenotypes, assessed categorically or quantitatively, have complex genetic bases. The ability to rapidly name letters, numbers, and colors from rows presented visually correlates strongly with reading in multiple languages and is a valid predictor of reading and spelling impairment. Performance on measures of rapid naming and switching, RAN and RAS, is stable throughout elementary school years, with slowed performance persisting in adults who still manifest dyslexia. Targeted analyses of dyslexia candidate regions have included RAN measures, but only one other genome‐wide linkage study has been reported. As part of a broad effort to identify genetic contributors to dyslexia, we performed combined oligogenic segregation and linkage analyses of measures of RAN and RAS in a family‐based cohort ascertained through probands with dyslexia. We obtained strong evidence for linkage of RAN letters to the DYX3 locus on chromosome 2p and RAN colors to chromosome 10q, but were unable to confirm the chromosome 6p21 linkage detected for a composite measure of RAN colors and objects in the previous genome‐wide study. © 2014 Wiley Periodicals, Inc.
ISSN:1552-4841
1552-485X
1552-485X
DOI:10.1002/ajmg.b.32237