Short-term effects of noisy pressure support ventilation in patients with acute hypoxemic respiratory failure

This study aims at comparing the very short-term effects of conventional and noisy (variable) pressure support ventilation (PSV) in mechanically ventilated patients with acute hypoxemic respiratory failure. Thirteen mechanically ventilated patients with acute hypoxemic respiratory failure were enrol...

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Bibliographic Details
Published in:Critical care (London, England) England), 2013-10, Vol.17 (5), p.R261-R261, Article R261
Main Authors: Spieth, Peter M, Güldner, Andreas, Huhle, Robert, Beda, Alessandro, Bluth, Thomas, Schreiter, Dierk, Ragaller, Max, Gottschlich, Birgit, Kiss, Thomas, Jaber, Samir, Pelosi, Paolo, Koch, Thea, Gama de Abreu, Marcelo
Format: Article
Language:English
Subjects:
Acute Disease
Adolescent
Adult
Aged
Artificial respiration
Complications and side effects
Cross-Over Studies
Diagnosis
Female
Germany
Health aspects
Hemodynamics
Humans
Hypoxia - physiopathology
Hypoxia - therapy
Male
Medical research
Medicine, Experimental
Middle Aged
Monitoring, Physiologic
Pulmonary Gas Exchange
Respiration, Artificial - methods
Respiratory insufficiency
Respiratory Insufficiency - physiopathology
Respiratory Insufficiency - therapy
Treatment Outcome
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Summary:This study aims at comparing the very short-term effects of conventional and noisy (variable) pressure support ventilation (PSV) in mechanically ventilated patients with acute hypoxemic respiratory failure. Thirteen mechanically ventilated patients with acute hypoxemic respiratory failure were enrolled in this monocentric, randomized crossover study. Patients were mechanically ventilated with conventional and noisy PSV, for one hour each, in random sequence. Pressure support was titrated to reach tidal volumes approximately 8 mL/kg in both modes. The level of positive end-expiratory pressure and fraction of inspired oxygen were kept unchanged in both modes. The coefficient of variation of pressure support during noisy PSV was set at 30%. Gas exchange, hemodynamics, lung functional parameters, distribution of ventilation by electrical impedance tomography, breathing patterns and patient-ventilator synchrony were analyzed. Noisy PSV was not associated with any adverse event, and was well tolerated by all patients. Gas exchange, hemodynamics, respiratory mechanics and spatial distribution of ventilation did not differ significantly between conventional and noisy PSV. Noisy PSV increased the variability of tidal volume (24.4 ± 7.8% vs. 13.7 ± 9.1%, P 
ISSN:1364-8535
1466-609X
1364-8535
DOI:10.1186/cc13091