ECM Inspired Coating of Embroidered 3D Scaffolds Enhances Calvaria Bone Regeneration

Resorbable polymeric implants and surface coatings are an emerging technology to treat bone defects and increase bone formation. This approach is of special interest in anatomical regions like the calvaria since adults lose the capacity to heal large calvarial defects. The present study assesses the...

Full description

Saved in:
Bibliographic Details
Published in:BioMed research international 2014-01, Vol.2014 (2014), p.1-15
Main Authors: Rammelt, Stefan, Förster, Yvonne, Bischoff, B., Scharnweber, Dieter, Bernhardt, R., Heinemann, Sascha, Rentsch, C., Rentsch, B.
Format: Article
Language:English
Subjects:
Absorbable Implants
Animals
Biomedical research
Bone regeneration
Bone Regeneration - drug effects
Bones
Cytokines
Defects
Extracellular matrix
Extracellular Matrix - metabolism
Extracellular Matrix - pathology
Heparan sulfate
Humans
Osteogenesis - drug effects
Polyesters - chemistry
Polyesters - therapeutic use
Polymethyl methacrylate
Rabbits
Skull - drug effects
Skull - growth & development
Skull base
Surgery
Tissue Engineering
Tissue Scaffolds
Transplants & implants
Ultrasonic imaging
Wound Healing
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Resorbable polymeric implants and surface coatings are an emerging technology to treat bone defects and increase bone formation. This approach is of special interest in anatomical regions like the calvaria since adults lose the capacity to heal large calvarial defects. The present study assesses the potential of extracellular matrix inspired, embroidered polycaprolactone-co-lactide (PCL) scaffolds for the treatment of 13 mm full thickness calvarial bone defects in rabbits. Moreover the influence of a collagen/chondroitin sulfate (coll I/cs) coating of PCL scaffolds was evaluated. Defect areas filled with autologous bone and empty defects served as reference. The healing process was monitored over 6 months by combining a novel ultrasonographic method, radiographic imaging, biomechanical testing, and histology. The PCL coll I/cs treated group reached 68% new bone volume compared to the autologous group (100%) and the biomechanical stability of the defect area was similar to that of the gold standard. Histological investigations revealed a significantly more homogenous bone distribution over the whole defect area in the PCL coll I/cs group compared to the noncoated group. The bioactive, coll I/cs coated, highly porous, 3-dimensional PCL scaffold acted as a guide rail for new skull bone formation along and into the implant.
ISSN:2314-6133
2314-6141
DOI:10.1155/2014/217078