Low hygiene and exposure to infections may be associated with increased risk for ulcerative colitis in a North Indian population

Previous studies have attempted to link hygiene hypothesis with IBD. However most of these studies come from developed countries where the level of hygiene is high and universal. Very little data is available from developing countries. The present study explores the truth of hygiene hypotheses and o...

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Published in:Annals of gastroenterology 2014, Vol.27 (3), p.219-223
Main Authors: Sood, Ajit, Amre, Devendra, Midha, Vandana, Sharma, Suresh, Sood, Neena, Thara, Amandeep, Bansal, Manu, Juyal, Garima, Thelma, Bittianda Kuttapa, Seidman, Ernest
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Language:English
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Summary:Previous studies have attempted to link hygiene hypothesis with IBD. However most of these studies come from developed countries where the level of hygiene is high and universal. Very little data is available from developing countries. The present study explores the truth of hygiene hypotheses and other risk factors for ulcerative colitis (UC) in a North Indian population where the prevalence of UC has been increasing. A total of 518 patients diagnosed with UC and 188 age-matched controls were included in the study. A structured questionnaire concerning socio-demographics and level of hygiene was completed by all participants. Logistic regression analysis was used to study the association between hygiene-related factors and the risk for UC. Odds ratios and 95% confidence intervals were estimated. There was a higher proportion of females (P
ISSN:1108-7471
1792-7463