Hippocampal Representation of Related and Opposing Memories Develop within Distinct, Hierarchically Organized Neural Schemas

Recent evidence suggests that the hippocampus may integrate overlapping memories into relational representations, or schemas, that link indirectly related events and support flexible memory expression. Here we explored the nature of hippocampal neural population representations for multiple features...

Full description

Saved in:
Bibliographic Details
Published in:Neuron (Cambridge, Mass.) Mass.), 2014-07, Vol.83 (1), p.202-215
Main Authors: McKenzie, Sam, Frank, Andrea J., Kinsky, Nathaniel R., Porter, Blake, Rivière, Pamela D., Eichenbaum, Howard
Format: Article
Language:English
Subjects:
Animals
Hippocampus - cytology
Hippocampus - physiology
Male
Memory - physiology
Nerve Net - cytology
Nerve Net - physiology
Neurons
Neurons - physiology
Psychomotor Performance - physiology
Random Allocation
Rats, Long-Evans
Reward
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Recent evidence suggests that the hippocampus may integrate overlapping memories into relational representations, or schemas, that link indirectly related events and support flexible memory expression. Here we explored the nature of hippocampal neural population representations for multiple features of events and the locations and contexts in which they occurred. Hippocampal networks developed hierarchical organizations of associated elements of related but separately acquired memories within a context, and distinct organizations for memories where the contexts differentiated object-reward associations. These findings reveal neural mechanisms for the development and organization of relational representations. [Display omitted] •Hippocampal ensembles form hierarchical representations of multiple task dimensions•Different features of events are represented successively•New information is encoded in extant networks that represent common information The hippocampus has been implicated in interleaving related memories into memory networks, called schemas. McKenzie et al. report that hippocampal neural ensembles form hierarchical representations that link related events by common dimensions, and these neural schemas rapidly assimilate new memories.
ISSN:0896-6273
1097-4199
DOI:10.1016/j.neuron.2014.05.019