Interventional therapy for human breast cancer in nude mice with 131I gelatin microspheres (¹³¹I-GMSs) following intratumoral injection

The aim of this study was to investigate the effects of 131I gelatin microspheres (131I-GMS) on human breast cancer cells (MCF-7) in nude mice and the biodistribution of 131I-GMSs following intratumoral injections. A total of 20 tumor-bearing mice were divided into a treatment group and control grou...

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Bibliographic Details
Published in:Radiation oncology (London, England) England), 2014-06, Vol.9 (1), p.144-144, Article 144
Main Authors: Li, Chuan-Chao, Chi, Jun-Lin, Ma, Yu, Li, Jian-Hong, Xia, Chuan-Qin, Li, Lin, Chen, Zhuo, Chen, Xiao-Li
Format: Article
Language:English
Subjects:
Animals
Breast Neoplasms - metabolism
Breast Neoplasms - pathology
Breast Neoplasms - radiotherapy
Female
Gelatin - administration & dosage
Gelatin - pharmacokinetics
Health aspects
Humans
Injections, Intralesional
Iodine Radioisotopes - administration & dosage
Iodine Radioisotopes - pharmacokinetics
MCF-7 Cells
Mice
Mice, Inbred BALB C
Mice, Nude
Microspheres
Radiopharmaceuticals - administration & dosage
Radiopharmaceuticals - pharmacokinetics
Radiotherapy
SPECT imaging
Tissue Distribution
Tomography, Emission-Computed, Single-Photon
Tumor Burden
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Summary:The aim of this study was to investigate the effects of 131I gelatin microspheres (131I-GMS) on human breast cancer cells (MCF-7) in nude mice and the biodistribution of 131I-GMSs following intratumoral injections. A total of 20 tumor-bearing mice were divided into a treatment group and control group and received intratumoral injections of 2.5 mci 131I-GMSs and nonradioactive GMSs, respectively. Tumor size was measured once per week. Another 16 mice received intratumoral injections of 0.4 mci 131I-GMSs and were subjected to single photon emission computed tomography (SPECT) scans and tissue radioactivity concentration measurements on day 1, 4, 8 and 16 postinjection. The 20 tumor-bearing mice received intratumoral injections of 0.4 mci [131I] sodium iodide solution and were subjected to SPECT scans and intratumoral radioactivity measurements at 1, 6, 24, 48 and 72 h postinjection. The tumors were collected for histological examination. The average tumor volume in the 131I-GMSs group on post-treatment day 21 decreased to 86.82 ± 63.6%, while it increased to 893.37 ± 158.12% in the control group (P 
ISSN:1748-717X
1748-717X
DOI:10.1186/1748-717X-9-144