High Mycoplasma genitalium Organism Burden Is Associated with Shedding of HIV-1 DNA from the Cervix

We assessed the relationship between infection with Mycoplasma genitalium, an emerging sexually transmitted pathogen, and cervical shedding of human immunodeficiency virus (HIV)-1 DNA among 303 HIV-1-positive Kenyan women. HIV-1 shedding was detected by qualitative polymerase chain reaction (PCR) in...

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Bibliographic Details
Published in:The Journal of infectious diseases 2008-03, Vol.197 (5), p.733-736
Main Authors: Manhart, Lisa E., Mostad, Sara B., Baeten, Jared M., Astete, Sabina G., Mandaliya, Kishorchandra, Totten, Patricia A.
Format: Article
Language:English
Subjects:
Adolescent
Adult
AIDS
Bacteriology
Biological and medical sciences
Cervix Uteri - virology
DNA, Viral
Female
Fundamental and applied biological sciences. Psychology
Genitalia
HIV
HIV 1
HIV Infections - complications
HIV/AIDS
Human immunodeficiency virus 1
Humans
Infections
Kenya
Microbiology
Middle Aged
Miscellaneous
Mycoplasma genitalium
Mycoplasma genitalium - pathogenicity
Mycoplasma Infections - complications
Neutrophils
Odds Ratio
Polymerase chain reaction
Sexually transmitted diseases
Uterine cervicitis
Virology
Virus Shedding
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Summary:We assessed the relationship between infection with Mycoplasma genitalium, an emerging sexually transmitted pathogen, and cervical shedding of human immunodeficiency virus (HIV)-1 DNA among 303 HIV-1-positive Kenyan women. HIV-1 shedding was detected by qualitative polymerase chain reaction (PCR) in 154 women (51%); M. genitalium was detected by qualitative PCR in 52 (17%), and organism burden was determined by quantitative PCR. Women with high M. genitalium organism burdens (more than the median of 3195 genomes/mL) were 3-fold more likely to shed HIV-1 DNA than were M. genitalium—negative women (adjusted OR, 2.9 [95% confidence interval, 1.1–7.6]), yet this did not appear to be mediated by traditional measures of cervical inflammation (elevated polymorphonuclear leukocyte count).
ISSN:0022-1899
1537-6613
DOI:10.1086/526501