Gradually Increased Training Intensity Benefits Rehabilitation Outcome after Stroke by BDNF Upregulation and Stress Suppression

Physical training is necessary for effective rehabilitation in the early poststroke period. Animal studies commonly use fixed training intensity throughout rehabilitation and without adapting it to the animals' recovered motor ability. This study investigated the correlation between training in...

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Bibliographic Details
Published in:BioMed research international 2014-01, Vol.2014 (2014), p.1-8
Main Authors: Ke, Zheng, Sun, Jing, Yip, Shea Ping, Hu, Xiao-ling, Zheng, Xiao-xiang, Tong, Kai-yu
Format: Article
Language:English
Subjects:
Animals
Biomedical research
Brain Ischemia - metabolism
Brain Ischemia - pathology
Brain Ischemia - rehabilitation
Brain-derived neurotrophic factor
Brain-Derived Neurotrophic Factor - metabolism
Care and treatment
Disease Models, Animal
Humans
Infarction, Middle Cerebral Artery - pathology
Male
Physical Conditioning, Animal
Physiological aspects
Rats
Rats, Sprague-Dawley
Stress (Psychology)
Stress, Physiological
Stroke (Disease)
Stroke - metabolism
Stroke - pathology
Stroke Rehabilitation
Treatment Outcome
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Summary:Physical training is necessary for effective rehabilitation in the early poststroke period. Animal studies commonly use fixed training intensity throughout rehabilitation and without adapting it to the animals' recovered motor ability. This study investigated the correlation between training intensity and rehabilitation efficacy by using a focal ischemic stroke rat model. Eighty male Sprague-Dawley rats were induced with middle cerebral artery occlusion/reperfusion surgery. Sixty rats with successful stroke were then randomly assigned into four groups: control (CG, n=15), low intensity (LG, n=15), gradually increased intensity (GIG, n=15), and high intensity (HG, n=15). Behavioral tests were conducted daily to evaluate motor function recovery. Stress level and neural recovery were evaluated via plasma corticosterone and brain-derived neurotrophic factor (BDNF) concentration, respectively. GIG rats significantly (P
ISSN:2314-6133
2314-6141
DOI:10.1155/2014/925762