Importing Mitochondrial Proteins: Machineries and Mechanisms

Most mitochondrial proteins are synthesized on cytosolic ribosomes and must be imported across one or both mitochondrial membranes. There is an amazingly versatile set of machineries and mechanisms, and at least four different pathways, for the importing and sorting of mitochondrial precursor protei...

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Bibliographic Details
Published in:Cell 2009-08, Vol.138 (4), p.628-644
Main Authors: Chacinska, Agnieszka, Koehler, Carla M., Milenkovic, Dusanka, Lithgow, Trevor, Pfanner, Nikolaus
Format: Article
Language:English
Subjects:
Adenosine Triphosphate - metabolism
Animals
Humans
Mitochondria - metabolism
Mitochondrial Proteins - chemistry
Mitochondrial Proteins - metabolism
Protein Sorting Signals
Protein Transport
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Summary:Most mitochondrial proteins are synthesized on cytosolic ribosomes and must be imported across one or both mitochondrial membranes. There is an amazingly versatile set of machineries and mechanisms, and at least four different pathways, for the importing and sorting of mitochondrial precursor proteins. The translocases that catalyze these processes are highly dynamic machines driven by the membrane potential, ATP, or redox reactions, and they cooperate with molecular chaperones and assembly complexes to direct mitochondrial proteins to their correct destinations. Here, we discuss recent insights into the importing and sorting of mitochondrial proteins and their contributions to mitochondrial biogenesis.
ISSN:0092-8674
1097-4172
DOI:10.1016/j.cell.2009.08.005