Incidence and Predisposing Factors of Vancomycin-Induced Nephrotoxicity in Children

Introduction To investigate the pattern of vancomycin-associated nephrotoxicity in children and to examine potential predisposing factors for nephrotoxicity, including average serum trough concentrations ≥10 μg/mL. Methods Patients ≥1 week old to ≤15 years with normal baseline serum creatinine value...

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Bibliographic Details
Published in:Infectious diseases and therapy 2013-06, Vol.2 (1), p.37-46
Main Authors: Ragab, Ahmed R., Al-Mazroua, Maha K., Al-Harony, Mona A.
Format: Article
Language:English
Subjects:
Antibiotics
Infectious Diseases
Internal Medicine
Kidney diseases
Medicine
Medicine & Public Health
Original Research
Pediatrics
Side effects
Toxicity
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Summary:Introduction To investigate the pattern of vancomycin-associated nephrotoxicity in children and to examine potential predisposing factors for nephrotoxicity, including average serum trough concentrations ≥10 μg/mL. Methods Patients ≥1 week old to ≤15 years with normal baseline serum creatinine values who received vancomycin for ≥48 h between October 2010 and September 2012 were retrospectively evaluated. Nephrotoxicity was defined as a serum creatinine increase of ≥0.5 mg/dL or ≥50% baseline increase over 2 days. Patients with average serum trough concentrations ≥10 μg/mL were compared with a lower trough group. Results Renal toxicity occurred in 72 (27.2%) of the 265 studied pediatric cases. High trough vancomycin levels ≥10 μg/mL were presented in 59 pediatric patients suffering from nephrotoxicity. Using multiple regression analysis, cases admitted to the intensive care unit (ICU) and to whom aminoglycoside medication was administered concurrently with vancomycin medication showed a significant high renal toxicity incidence [odds ratio (OR) 2.91; 95% confidence interval (CI) 1.70, 8.61; P value
ISSN:2193-8229
2193-6382
DOI:10.1007/s40121-013-0004-8