Liposomes containing monophosphoryl lipid A: A potent adjuvant system for inducing antibodies to heroin hapten analogs

• Published in: Vaccine 2013-06, Vol.31 (26), p.2804-2810
• Main Authors: Matyas, Gary R, Mayorov, Alexander V, Rice, Kenner C, Jacobson, Arthur E, Cheng, Kejun, Iyer, Malliga R, Li, Fuying, Beck, Zoltan, Janda, Kim D, Alving, Carl R
• Format: Article
• Language: English
• Subjects: Addictive behaviors; Adjuvant system; Adjuvants; Adjuvants, Immunologic - administration & dosage; Adjuvants, Immunologic - chemistry; Adult and adolescent clinical studies; Allergy and Immunology; Aluminum; Alzheimer's disease; Amino acids; Animals; antibodies; Antibodies to heroin haptens; Antibody Formation; Applied microbiology; Binding sites; Biological and medical sciences; Cancer; Competition; Drug abuse; Drug addiction; Epitopes, T-Lymphocyte - chemistry; Epitopes, T-Lymphocyte - immunology; Feasibility Studies; Female; Fundamental and applied biological sciences. Psychology; haptens; Haptens - chemistry; Haptens - immunology; Heroin; Heroin - immunology; HIV Envelope Protein gp41 - chemistry; HIV Envelope Protein gp41 - immunology; Human immunodeficiency virus 1; hydrophobicity; Immunization; immunoglobulin G; Immunology; Laboratory animals; lipid A; Lipid A - administration & dosage; Lipid A - analogs & derivatives; Lipid A - chemistry; Lipid A - immunology; Lipids; Liposomes; Liposomes containing monophosphoryl lipid A; Medical sciences; Mice; Mice, Inbred BALB C; Microbiology; mixing; Opiate vaccine; Opioid-Related Disorders - immunology; Opioid-Related Disorders - prevention & control; Peptides; Peptides - chemistry; Peptides - immunology; Proteins; Psychology. Psychoanalysis. Psychiatry; Psychopathology. Psychiatry; Studies; T-lymphocytes; tetanus; Tetanus Toxoid - chemistry; Tetanus Toxoid - immunology; Vaccines; Vaccines - immunology; Vaccines, antisera, therapeutical immunoglobulins and monoclonal antibodies (general aspects)
• ISSN: 0264-410X; 1873-2518; 1873-2518
• DOI: 10.1016/j.vaccine.2013.04.027

Highlights • Liposomes with monophosphoryl lipid A were formulated as adjuvants for haptens. • Heroin analog haptens were conjugated either to the liposomes or to tetanus toxoid. • Enhanced antibody titers were induced to liposome-conjugated haptens. • Enhanced antibody titers were also induced to haptens conjugated to the toxoid. • Liposomal monophosphoryl lipid A could strongly adjuvant an anti-heroin vaccine.