Maternal low glycaemic index diet, fat intake and postprandial glucose influences neonatal adiposity – secondary analysis from the ROLO study

• Published in: Nutrition journal 2014-08, Vol.13 (1), p.78-78, Article 78
• Main Authors: Horan, Mary K, McGowan, Ciara A, Gibney, Eileen R, Donnelly, Jean M, McAuliffe, Fionnuala M
• Format: Article
• Language: English
• Subjects: Adiposity; Adult; Analysis; arm circumference; Birth weight; Blood Glucose - metabolism; Body Height; Body Mass Index; Body Weight; Clinical trials; Demographics; Diet; Diet Records; Dietary Carbohydrates - administration & dosage; Dietary Fats - administration & dosage; Dietary Proteins - administration & dosage; Editing; energy; Energy Intake; Exercise; fat intake; Fatty Acids - administration & dosage; Fatty Acids, Monounsaturated - administration & dosage; Fatty Acids, Unsaturated - administration & dosage; Feeding Behavior; Female; fetal development; Fetal Macrosomia - prevention & control; Fetuses; food records; Glucose; Glucose Tolerance Test; Glycemic Index; Growth hormones; healthy diet; Hospitals; Humans; Infant; Insulin; Life Style; lifestyle; Lifestyles; Linear Models; maternal nutrition; Maternal Nutritional Physiological Phenomena; Medical research; Nutrition research; nutritional intervention; physical activity; Physical fitness; Physiological aspects; Postprandial Period; Pregnancy; Proteins; Questionnaires; regression analysis; Studies; Surveys and Questionnaires; University colleges; Weight Gain; Womens health
• ISSN: 1475-2891; 1475-2891
• DOI: 10.1186/1475-2891-13-78

BACKGROUND: The in utero environment is known to affect fetal development however many of the mechanisms by which this occurs remain unknown. The aim of this study was to examine the association between maternal dietary macronutrient intake and lifestyle throughout pregnancy and neonatal weight and adiposity. METHODS: This was an analysis of 542 mother and infant pairs from the ROLO study (Randomised cOntrol trial of LOw glycaemic index diet versus no dietary intervention to prevent recurrence of fetal macrosomia). Food diaries as well as food frequency and lifestyle and physical activity questionnaires were completed during pregnancy. Maternal anthropometry was measured throughout pregnancy and neonatal anthropometry was measured at birth. RESULTS: Multiple linear regression analysis revealed the main maternal factor associated with increased birth weight was greater gestational weight gain R² ₐdⱼ23.3% (F = 11.547, p