Spinal root avulsion： an excellent model for studying motoneuron degeneration and regeneration after severe axonal injury

Spinal root avulsion is an excellent model for studying the re- sponse of motoneurons to severe injury to their axons （Koliat- sos et al., 1994）. In this model （‘Avulsion Model＇）, spinal roots are torn off from spinal cord without removing the vertebra at different levels of spinal segments, usually...

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Bibliographic Details
Published in:Neural regeneration research 2014-01, Vol.9 (2), p.117-118
Main Authors: Ruven, Carolin, Chan, Tak-Kwong, Wu, Wutian
Format: Article
Language:English
Subjects:
Atrophy
Degeneration
Injuries
Nerves, Peripheral
Nervous system
Risk factors
Spinal cord
Spinal cord injuries
中枢神经系统
再生
变性
模型
神经损伤
脊神经
轴突
运动神经元
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Summary:Spinal root avulsion is an excellent model for studying the re- sponse of motoneurons to severe injury to their axons （Koliat- sos et al., 1994）. In this model （‘Avulsion Model＇）, spinal roots are torn off from spinal cord without removing the vertebra at different levels of spinal segments, usually at cervical and lum- bar segments. Step-by-step procedures are described in detail elsewhere （Chu and Wu, 2009）. The Avulsion Model resembles very well brachial plexus injuries in human beings. Around 70% of severe brachial plexus injuries in human involved avulsion of one or more roots （Narakas, 1985） and the main causes of traumatic brachial plexus injuries were motor vehicle accidents, sport injuries and difficult deliveries （Terzis et al., 2001）. The Avulsion Model involves injury to both central nervous system （CNS） and peripheral nervous system （PNS） while nerve axoto- my, transection and crush injuries only involve PNIS.
ISSN:1673-5374
1876-7958
DOI:10.4103/1673-5374.125338