Current Progress in Reactive Oxygen Species (ROS)-Responsive Materials for Biomedical Applications

Recently, significant progress has been made in developing “stimuli‐sensitive” biomaterials as a new therapeutic approach to interact with dynamic physiological conditions. Reactive oxygen species (ROS) production has been implicated in important pathophysiological events, such as atherosclerosis, a...

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Bibliographic Details
Published in:Advanced healthcare materials 2013-06, Vol.2 (6), p.908-915
Main Authors: Lee, Sue Hyun, Gupta, Mukesh K., Bang, Jae Beum, Bae, Hojae, Sung, Hak-Joon
Format: Article
Language:English
Subjects:
Abnormalities
Aging
Animals
Arteriosclerosis
Atherosclerosis
Biocompatible Materials - chemistry
Biocompatible Materials - pharmacology
Biomaterials
Biomedical materials
degradation
Material properties
Oxygen
Pathogenesis
Reactive oxygen species
Reactive Oxygen Species - chemistry
Reactive Oxygen Species - metabolism
Solubility
solubility switch
therapeutic delivery
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Summary:Recently, significant progress has been made in developing “stimuli‐sensitive” biomaterials as a new therapeutic approach to interact with dynamic physiological conditions. Reactive oxygen species (ROS) production has been implicated in important pathophysiological events, such as atherosclerosis, aging, and cancer. ROS are often overproduced locally in diseased cells and tissues, and they individually and synchronously contribute to many of the abnormalities associated with local pathogenesis. Therefore, the advantages of developing ROS‐responsive materials extend beyond site‐specific targeting of therapeutic delivery, and potentially include navigating, sensing, and repairing the cellular damages via programmed changes in material properties. Here we review the mechanism and development of biomaterials with ROS‐induced solubility switch or degradation, as well as their performance and potential for future biomedical applications. The recent development of reactive oxygen species (ROS)‐responsive materials is inspired by numerous disease states, such as cancer and inflammation, involving the overproduction of ROS. ROS‐responsive materials available today employ two general mechanisms: i) solubility switch and ii) degradation upon exposure to ROS. These materials can be used for drug and cell delivery to interact with the pathophysiological states more intelligently.
ISSN:2192-2640
2192-2659
DOI:10.1002/adhm.201200423