Induced urinary crystal formation as an analytical strategy for the prediction and monitoring of urolithiasis and other metabolism-related disorders

Crystal formation reflects the entire composition of the surrounding solution. In case of urolithiasis, induced crystal formation in native urine has led to the development of the Bonn-Risk-Index (BRI), a valuable tool to quantify an individual's risk of calcium oxalate urolithiasis. If the pro...

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Bibliographic Details
Published in:The EPMA journal 2014-08, Vol.5 (1), p.13-13, Article 13
Main Authors: Laube, Norbert, Berg, Wolfgang, Bernsmann, Falk, Gravius, Sascha, Klein, Florian, Latz, Stefan, Mallek, Dirk von, Porowski, Tadeusz, Randau, Thomas, Wasilewska, Anna, Fisang, Christian
Format: Article
Language:English
Subjects:
Biomedical and Life Sciences
Biomedicine
Calculi, Urinary
Crystals
Development and progression
Ice
Medicine/Public Health
Oxalates
Oxalic acid
Physiological aspects
Review
Structure
Twinning (Crystallography)
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Summary:Crystal formation reflects the entire composition of the surrounding solution. In case of urolithiasis, induced crystal formation in native urine has led to the development of the Bonn-Risk-Index (BRI), a valuable tool to quantify an individual's risk of calcium oxalate urolithiasis. If the progression of a disease is associated with characteristic changes in the activities of urinary components, this leads to an altered urinary crystallisation capacity. Therefore, the results of induced urinary crystal formation can be used to detect and monitor any disease linked to the altered urinary composition. Since crystal formation inherently takes into account the entire urinary composition, the influence of the disease on individual urinary parameters does not have to be known in order to monitor the consequent pathologic alterations. In this paper, we review the background of urinary crystal formation analysis and describe its established application in urolithiasis monitoring as well as potential further fields of clinical application.
ISSN:1878-5077
1878-5085
DOI:10.1186/1878-5085-5-13