Early life perfluorooctanesulphonic acid (PFOS) exposure impairs zebrafish organogenesis

•We found PFOS exposure produced uninflated swim bladder and less developed gut.•We examined the histological alterations induced by PFOS.•We examined the detailed structural changes using histology and TEM analysis.•The whole genomic expressions were performed under PFOS window exposure.•Pathways/g...

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Bibliographic Details
Published in:Aquatic toxicology 2014-05, Vol.150, p.124-132
Main Authors: Chen, Jiangfei, Tanguay, Robert L., Tal, Tamara L., Gai, Zengxin, Ma, Xue, Bai, Chenglian, Tilton, Susan C., Jin, Daqing, Yang, Dongren, Huang, Changjiang, Dong, Qiaoxiang
Format: Article
Language:English
Subjects:
Air Sacs - embryology
Alkanesulfonic Acids - toxicity
Animals
Biological and medical sciences
Developmental toxicity
Embryo, Nonmammalian
Embryology: invertebrates and vertebrates. Teratology
Environmental Exposure
Fluorocarbons - toxicity
Fundamental and applied biological sciences. Psychology
Gene Expression Regulation, Developmental - drug effects
Gut
Intestines - embryology
Organogenesis - drug effects
Perfluorooctanesulfonic acid
Swim bladder
Teratology. Teratogens
Water Pollutants, Chemical - toxicity
Zebrafish - embryology
Zebrafish - genetics
Zebrafish embryo
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Summary:•We found PFOS exposure produced uninflated swim bladder and less developed gut.•We examined the histological alterations induced by PFOS.•We examined the detailed structural changes using histology and TEM analysis.•The whole genomic expressions were performed under PFOS window exposure.•Pathways/genes involved in the PFOS perturbed organogenesis were identified. As a persistent organic contaminant, perfluorooctanesulphonic acid (PFOS) has been widely detected in the environment, wildlife, and humans. The present study revealed that zebrafish embryos exposed to 16μM PFOS during a sensitive window of 48–96hour post-fertilization (hpf) disrupted larval morphology at 120hpf. Malformed zebrafish larvae were characterized by uninflated swim bladder, less developed gut, and curved spine. Histological and ultrastructural examination of PFOS-exposed larvae showed structural alterations in swim bladder and gut. Whole genome microarray was used to identify the early transcripts dysregulated following exposure to 16μM PFOS at 96hpf. In total, 1278 transcripts were significantly misexpressed (p
ISSN:0166-445X
1879-1514
DOI:10.1016/j.aquatox.2014.03.005